CHO-Ph-CONH-PEG2-acid
CAS No.: 1807534-84-4
Cat No.: BP-501171
Purity: ≥95%
4.5 
CHO-Ph-CONH-PEG2-acid is a PEG-based PROTAC linker featuring a terminal carboxylic acid and a formylphenyl amide segment connected through a short PEG2 spacer. Structurally, the linker combines a hydrophilic PEG segment with an aromatic/amide region, providing both solubility and conformational flexibility while maintaining a carboxylic acid coupling site while the aromatic aldehyde can participate in oxime/hydrazone formation or reductive amination. In PROTAC architectures, such linkers help position the two binding partners in a productive geometry to promote formation of the ternary complex and subsequent ubiquitination and degradation of the target protein. The short PEG length and amide linkage are particularly useful when researchers need minimal spacer extension yet require improved aqueous handling and reduced aggregation. Overall, this linker supports systematic optimization of linker length and attachment chemistry, enabling reproducible targeted degradation studies and structure–activity relationship exploration.
Structure of 1807534-84-4
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This PROTAC linker, CHO-Ph-CONH-PEG2-acid, is designed to connect a protein-binding ligand to an E3-recruiting moiety through a flexible PEG-containing spacer and a carboxylic acid handle. Its balanced polarity and conformational flexibility can help maintain productive ternary-complex formation and improve synthetic modularity. The detailed Structure and Reactivity parameters for constructing PROTACs using this linker are provided below.
Structure: The linker incorporates an ether-based PEG segment for conformational flexibility, a phenyl ring bearing an aldehyde group for aromatic rigidity and carbonyl reactivity, and an amide linkage that supports stable conjugation chemistry. A terminal carboxylic acid provides a chemically addressable site for coupling, while ether oxygen atoms increase hydrophilicity and solubility.
Reactivity: The carboxylic acid group is suitable for standard PROTAC linker coupling strategies, typically via activation to form an acyl intermediate followed by nucleophilic amide bond formation with an amine-bearing partner; the aromatic aldehyde can separately participate in imine formation or reductive amination with primary amines. Common approaches use carbodiimide-type activators with coupling additives in polar aprotic or mixed aqueous/organic solvents. The PEG spacer generally remains inert under these conditions, preserving linker integrity and enabling modular assembly of bifunctional degraders.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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