Diethylene Glycol Bis(2-propynyl) Ether
CAS No.: 126422-57-9
Cat No.: BP-500963
Purity: >95%
4.5 
Diethylene Glycol Bis(2-propynyl) Ether is a bifunctional propargyl ether linker featuring a diethylene glycol core bearing two terminal alkyne (2-propynyl) groups. The linker’s flexible polyether backbone provides conformational mobility, while the two reactive alkynes enable orthogonal conjugation strategies commonly used in PROTAC construction. In targeted protein degradation workflows, this type of bis-propargyl linker is typically used to connect or extend two PROTAC-relevant modules (e.g., a ligand for an E3 ligase and a ligand for the target protein) through copper-catalyzed azide–alkyne cycloaddition (“click” chemistry) or related alkyne-based coupling, allowing controlled placement of the two binding elements. Its dual-end reactivity supports systematic linker-length and geometry optimization, which is critical for tuning ternary complex formation and degradation potency. Overall, it is a practical reagent for assembling modular PROTACs and for generating linker variants to probe structure–activity relationships.
Structure of 126422-57-9
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Diethylene Glycol Bis(2-propynyl) Ether is a bifunctional propargyl ether linker designed to enable efficient modular assembly of PROTAC constructs through orthogonal “click” chemistry. Its two terminal alkyne handles support controlled conjugation to complementary ligands, helping researchers build targeted protein degraders with defined linker geometry and reliable attachment points. The detailed structural and synthetic considerations for using this molecule in PROTAC workflows are provided below.
Structure: The linker contains a diethylene glycol ether core bearing two propargyl (terminal alkyne) substituents. It features ether linkages that provide conformational flexibility, along with carbon–carbon triple bonds that serve as reactive alkyne functionalities. Overall, it is an organic, bifunctional small molecule suitable for stepwise bioconjugation.
Reactivity: Terminal alkynes react under copper-catalyzed azide–alkyne cycloaddition conditions to form stable triazole linkages, a widely used strategy in PROTAC synthesis. Typical approaches employ a Cu(I) source generated in situ, an appropriate ligand to stabilize catalysis, and polar organic solvents or mixed solvent systems compatible with the azide-bearing partners. Reaction proceeds via formation of a copper–acetylide intermediate followed by cycloaddition to the azide, enabling modular assembly of degradation molecules.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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