Name: Fmoc-N-amido-PEG6-propionic acid
Brand: BOC Sciences
Rating: 5 (1 reviews)

Size

Price

Stock

Quantity

$--

In stock

Purity

≥95%

Solubility

Soluble in DMSO (Slightly), Methanol (Slightly)

Appearance

Colorless to light yellow clear liquid

Storage

Store at 2-8°C

Shipping

Room temperature

IUPACName

3-[2-[2-[2-[2-[2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid

Synonyms

Fmoc-N-amido-PEG6-acid; Fmoc-21-amino-4,7,10,13,16,19-hexaoxaheneicosanoic acid; 5,8,11,14,17,20-Hexaoxa-2-azatricosanedioic acid, 1-(9H-fluoren-9-ylmethyl) ester; Fmoc-NH-PEG6-CH2CH2COOH; 1-(9H-Fluoren-9-yl)-3-oxo-2,7,10,13,16,19,22-heptaoxa-4-azapentacosan-25-oic acid; (Fmoc-amino)-PEG6-carboxylic Acid; 21-(Fmoc-amino)-4,7,10,13,16,19-hexaoxahenicosanoic Acid; 21-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-4,7,10,13,16,19-hexaoxahenicosanoic Acid

Boiling Point

734.8±60.0 °C at 760 mmHg

Density

1.202±0.06 g/cm3 at 20°C, 760 Torr

InChI Key

HEGZERUHBVYZPH-UHFFFAOYSA-N

InChI

InChI=1S/C30H41NO10/c32-29(33)9-11-35-13-15-37-17-19-39-21-22-40-20-18-38-16-14-36-12-10-31-30(34)41-23-28-26-7-3-1-5-24(26)25-6-2-4-8-27(25)28/h1-8,28H,9-23H2,(H,31,34)(H,32,33)

SMILES

C1=CC=C2C(=C1)C(C3=CC=CC=C32)COC(=O)NCCOCCOCCOCCOCCOCCOCCC(=O)O

Biological Activity

Fmoc-NH-PEG6-CH2CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1] . In Vitro: ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

This Fmoc-N-amido-PEG6-propionic acid linker is designed to provide a flexible, hydrophilic polyethylene glycol spacer for constructing PROTACs and related targeted degradation conjugates. Its Fmoc-protected amide functionality enables controlled coupling chemistry, while the PEG segment supports solubility and favorable linker presentation between the ligand-binding moieties. The following sections describe its structure and practical reactivity considerations in PROTAC assembly.

Structure: The linker contains an Fmoc-protected amide linked to a PEG-based spacer and a terminal propionic acid functionality. It features aromatic carbamate character from Fmoc, amide and ether linkages within the PEG chain, and a carboxylic acid for conjugation. Overall, it is a polar, water-compatible scaffold.

Reactivity: The terminal carboxylic acid can be activated for amide-bond formation using standard coupling chemistries commonly employed in PROTAC synthesis. Typical approaches include carbodiimide-mediated activation with an amine-containing partner, often in polar aprotic solvents and under mild base conditions to promote nucleophilic acyl substitution. The Fmoc group is generally removed under base-promoted conditions when deprotection is required prior to coupling, enabling stepwise linker assembly.

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* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C₁V₁ = C₂V₂