t-boc-N-amido-PEG3-alcohol
CAS No.: 139115-92-7
Cat No.: BP-500008
Purity: >95%
4.5 
t-Boc-N-amido-PEG3-alcohol is a PEG-based linker building block featuring a Boc-protected amide functionality and a short, three-unit poly(ethylene glycol) chain terminating in a primary alcohol. Structurally, the PEG segment provides conformational flexibility and aqueous solubility, while the amide handle enables controlled conjugation chemistry through standard coupling or derivatization strategies. In PROTAC and targeted protein degradation designs, this linker is used to spatially separate the ligand-binding warhead from the recruiting or E3-binding module, tuning effective ternary-complex formation by modulating linker length, polarity, and local dynamics. The terminal alcohol can be converted into activated derivatives (e.g., esters or ethers) to facilitate attachment to carboxylate- or hydroxyl-bearing partners, supporting stepwise assembly of degraders. This compound is valuable for researchers seeking reliable, modular PEG linkers to optimize degradation potency and selectivity while maintaining synthetic tractability and compatibility with iterative PROTAC synthesis workflows.
Structure of 139115-92-7
Assurance
Delivery
Support
* For research and manufacturing use only. Not for human or clinical use.
| Size | Price | Stock | Quantity |
|---|---|---|---|
| -- | $-- | In stock |
Looking for different specifications? Click to request a custom quote!
Capabilities & Facilities
- Comprehensive PROTAC Platform
- Scientific Expertise & Technical Support
- Custom Synthesis & Design Service
- Extensive Product Coverage
- Cutting-Edge Innovation
- Fast Delivery & Global Support
- 24/7 customer service
- 100% quality assurance
Popular Publications Citing BOC Sciences Products
t-boc-N-amido-PEG3-alcohol, is a PEG-based, functionalized alcohol designed to serve as a flexible spacer for assembling bifunctional degraders. Its ether-rich backbone provides conformational mobility and improved solubility, while the protected amide functionality enables controlled coupling to targeting ligands and E3-recruiting warheads. The alcohol handle supports site-selective derivatization, making it well suited for linker engineering in targeted protein degradation workflows. The following points describe its structural and synthetic reactivity in detail below.
Structure: The molecule contains a short polyethylene glycol segment featuring ether linkages, terminating in an alcohol group for further functionalization. An amide motif is present and protected as a Boc carbamate, providing stability under many coupling conditions while enabling deprotection when required. The combination yields a flexible, polar linker.
Reactivity: The terminal alcohol can be activated for nucleophilic substitution or ester formation, enabling attachment to complementary PROTAC fragments under standard organic coupling strategies. The Boc-protected amide allows orthogonal synthesis: Boc can be removed using acid-mediated deprotection to reveal an amine for amide bond formation or urea/carbamate-type coupling. Typical approaches employ coupling reagents and polar aprotic solvents, with reaction conditions selected to preserve the PEG ether backbone and avoid side reactions.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
Related Product Recommendations
Please contact us with any specific requirements and we will get back to you as soon as possible.
