Fmoc-N-PEG23-acid
Cat No.: BP-501880
4.5 
Fmoc-N-PEG23-acid is an Fmoc-protected, carboxy-terminated polyethylene glycol linker designed for stepwise synthesis of PROTACs and other targeted conjugates. Structurally, it comprises an Fmoc carbamate at one terminus and a terminal carboxylic acid at the other, connected by a long, flexible PEG chain that provides a defined hydrophilic spacer and conformational freedom. In PROTAC architectures, such PEG linkers are commonly used to tune the spatial relationship between the target-binding ligand and the E3-recruiting module, helping to reduce steric clashes, improve effective intramolecular proximity, and maintain solubility of the final degrader. The terminal acid enables straightforward coupling to amine- or hydrazide-containing partners via standard peptide-conjugation chemistries, facilitating robust linker installation during iterative synthesis. This product is valuable for researchers seeking modular, reproducible linker control to optimize degradation potency and physicochemical properties in targeted protein degradation studies.
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* For research and manufacturing use only. Not for human or clinical use.
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Fmoc-N-PEG23-acid is a polyethylene glycol-based PROTAC linker building block designed to provide flexible spacing between a target-binding ligand and an E3 ligase recruiter. Its polyethylene glycol segment supports favorable solubility and conformational adaptability, while the Fmoc-protected functionality enables controlled stepwise synthesis. The resulting linkers are widely used in targeted protein degradation workflows to tune linker length and physicochemical behavior; detailed structure and reaction guidance are provided below.
Structure: The linker comprises an Fmoc-protected amine connected to a PEG chain terminating in a carboxylic acid. It contains aromatic carbamate functionality, ether-rich PEG segments, and a terminal acid suitable for amide coupling. Overall, it is flexible, polar, and typically water-compatible.
Reactivity: The terminal carboxylic acid is commonly converted to activated esters for amide bond formation with amine-bearing ligands under standard coupling conditions. Fmoc chemistry is used for orthogonal protection/deprotection during assembly, typically employing base-mediated Fmoc removal followed by coupling. Suitable reagents include carbodiimide-based activators with auxiliary coupling additives, using polar aprotic solvents; reaction progress is monitored by chromatography or mass spectrometry.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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