FmocNH-PEG3-CH2CH2NH2 HCl
CAS No.: 906079-91-2
Cat No.: BP-502145
Purity: >97%
4.5 
FmocNH-PEG3-CH2CH2NH2 HCl is a protected, amino-terminated polyethylene glycol (PEG) linker designed for stepwise PROTAC synthesis. Structurally, it contains an Fmoc-protected amine for orthogonal solid-phase or solution-phase coupling, a short PEG3 spacer that provides aqueous solubility and conformational flexibility, and a terminal primary amine that serves as a reactive handle for amide or urea bond formation. In targeted protein degradation constructs, such linkers help transmit spatially defined connectivity between a ligand-recruiting module and an E3-ligase-binding ligand, reducing steric clashes while allowing the ternary complex to form more productively. The PEG segment can also mitigate aggregation and improve handling of bulky conjugates. As a versatile building block, it enables systematic variation of linker geometry in PROTAC libraries and supports reproducible conjugation strategies for mechanistic and optimization studies.
Structure of 906079-91-2
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This FmocNH-PEG3-CH2CH2NH2 HCl is a polyethylene glycol-based linker designed for constructing PROTACs and related targeted protein degradation conjugates. The Fmoc-protected amine enables controlled stepwise assembly, while the PEG segment provides conformational flexibility and improved solubility for efficient linker–warhead coupling. Its terminal primary amine allows straightforward functionalization to connect E3 ligands and target-binding moieties. The detailed Structure and Reactivity parameters are provided below.
Structure: The linker contains an Fmoc-protected nitrogen, a PEG-derived flexible spacer, and a terminal primary amine as its hydrochloride salt. It features aromatic carbamate chemistry from the Fmoc group, ether linkages within the PEG chain, and aliphatic C–N and C–C bonds, contributing to enhanced aqueous compatibility.
Reactivity: PROTAC assembly commonly uses the terminal primary amine for amide or urea formation with activated carboxylic acids or isocyanates, or for reductive amination with suitable carbonyl partners. Fmoc removal is typically performed under base conditions compatible with peptide/bioconjugation workflows, followed by coupling using standard peptide-coupling reagents. Solvents such as DMF or DCM are frequently used for coupling steps, while aqueous co-solvents can support salt-form amine handling.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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