HO-PEG24-CH2CH2COOH
Cat No.: BP-502117
4.5 
HO-PEG24-CH2CH2COOH is a hydrophilic polyethylene glycol (PEG) linker bearing a terminal carboxylic acid and a short ethylene spacer, providing a flexible, water-soluble tether for connecting two functional moieties in PROTAC architectures. Structurally, it consists of a long PEG chain that can reduce steric interference and improve effective reach between the ligand-binding groups, while the terminal –CH2CH2–COOH handle enables robust amide coupling or related conjugation to activated carboxylate/amine partners. In targeted protein degradation designs, such linkers are used to spatially position the E3-ligase-binding ligand and the target-binding ligand so that the ternary complex can form efficiently, while the PEG segment can enhance solubility and mitigate aggregation that would otherwise impair binding. This product is valuable for systematic linker optimization, allowing researchers to tune length and hydrophilicity to improve degradation potency and experimental reproducibility across PROTAC variants.
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* For research and manufacturing use only. Not for human or clinical use.
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This HO-PEG24-CH2CH2COOH linker is a polyethylene glycol-based bifunctional spacer designed to connect a targeting ligand to an E3-recruiting moiety in PROTAC constructs. Its hydrophilic, flexible PEG architecture helps tune linker length, conformational freedom, and overall solubility, often improving practical handling and maintaining favorable proximity between binding elements. The carboxylic acid functionality provides a versatile handle for coupling strategies used in targeted protein degradation. Detailed structural and reactivity considerations are provided below.
Structure: HO-PEG24-CH2CH2COOH is a PEG chain bearing terminal hydroxyl and carboxylic acid groups, connected through an ethylene spacer. It contains ether linkages along the polymer backbone and a terminal aliphatic chain terminating in a carboxyl group, conferring high polarity and water compatibility.
Reactivity: The terminal carboxylic acid enables standard PROTAC linker conjugation via amide-bond formation or related acyl-derivatization routes. Typical approaches use carbodiimide coupling with an amine-containing partner, or activation to an acid chloride or activated ester followed by nucleophilic substitution. Mild, aqueous or mixed aqueous/organic solvents are commonly employed, with base and coupling reagents to drive condensation while minimizing side reactions.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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