Hydroxy-PEG6-acetic acid
CAS No.: 120394-66-3
Cat No.: BP-501635
Purity: >97%
4.5 
Hydroxy-PEG6-acetic acid is a polyethylene glycol (PEG) linker bearing a terminal hydroxyl group and a carboxylic acid (acetic acid) functionality, providing a flexible, water-compatible chain of approximately six ethylene glycol units. Structurally, it is well suited for PROTAC and targeted protein degradation constructs where linker length and conformational mobility strongly influence ternary complex formation, degradation potency, and overall physicochemical properties. In PROTAC design, the PEG segment acts as a spacing and solubilizing element that can reduce steric clashes between the ligand-recruiting warhead and the E3 ligase binder, while the terminal hydroxyl and carboxyl groups enable chemical conjugation through standard coupling or derivatization strategies to attach to neighboring functional moieties. This linker is particularly valuable for optimizing soluble, bioconjugatable degradation reagents and for systematically tuning linker effects during SAR studies.
Structure of 120394-66-3
Assurance
Delivery
Support
* For research and manufacturing use only. Not for human or clinical use.
| Size | Price | Stock | Quantity |
|---|---|---|---|
| -- | $-- | In stock |
Looking for different specifications? Click to request a custom quote!
Capabilities & Facilities
- Comprehensive PROTAC Platform
- Scientific Expertise & Technical Support
- Custom Synthesis & Design Service
- Extensive Product Coverage
- Cutting-Edge Innovation
- Fast Delivery & Global Support
- 24/7 customer service
- 100% quality assurance
Popular Publications Citing BOC Sciences Products
Hydroxy-PEG6-acetic acid is a polyethylene glycol-based PROTAC linker building block designed to provide hydrophilicity, conformational flexibility, and controlled spatial separation between a targeting ligand and an E3-recruiting moiety. Its ether-rich backbone and terminal functional group support robust conjugation strategies commonly used in targeted protein degradation workflows. The points below describe its structure and practical reactivity considerations for constructing PROTACs in research settings.
Structure: The linker consists of a PEG chain terminated by a hydroxyl group and an acetic acid functionality. It contains multiple ether linkages along a flexible polyether backbone, with hydrogen-bonding capacity from the hydroxyl and carboxylic acid groups, supporting water compatibility and stable, non-covalent conformational effects.
Reactivity: The carboxylic acid enables standard amide or ester-forming coupling to PROTAC ligand scaffolds under dehydrating coupling conditions using common carbodiimide or uronium-type reagents, often with base in polar aprotic solvents. The hydroxyl group can be activated for ether formation or used for further derivatization. Mechanistically, activation of the acid followed by nucleophilic substitution yields stable linkages suitable for PROTAC assembly.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
Related Product Recommendations
Please contact us with any specific requirements and we will get back to you as soon as possible.
