Hydroxy-PEG7-acetic acid
CAS No.: 2250056-27-8
Cat No.: BP-501154
Purity: >95%
4.5 
Hydroxy-PEG7-acetic acid is a polyethylene glycol–based linker bearing a terminal hydroxyl group and an acetic acid functional group, providing a flexible, water-compatible chain of intermediate length suitable for bioconjugation. In PROTAC architectures, PEG linkers are widely used to tune the spatial relationship between the ligand that recruits the E3 ligase and the ligand that binds the target protein, thereby improving productive ternary complex formation and reducing steric clashes. The hydroxyl and carboxylic acid termini enable straightforward synthetic coupling strategies, such as activation of the carboxyl group for amide bond formation or derivatization at the hydroxyl end to introduce orthogonal handles for sequential assembly. Its hydrophilicity and conformational flexibility can enhance solubility and often improve experimental handling of conjugates, making it a useful building block for linker optimization in targeted protein degradation research.
Structure of 2250056-27-8
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Hydroxy-PEG7-acetic acid is a polyethylene glycol (PEG)-based linker designed to support PROTAC assembly by providing a hydrophilic, flexible spacer between a targeting ligand and an E3-recruiting moiety. Its ether-rich backbone helps tune solubility and conformational freedom, which can improve productive ternary complex formation in targeted protein degradation workflows. The structure and reactivity considerations for constructing PROTACs with this linker are described in detail below.
Structure: The linker contains a PEG chain featuring multiple ether linkages, terminated by a hydroxyl group and an acetic acid functionality. This combination yields a flexible, water-compatible scaffold with hydrogen-bonding capacity from the terminal hydroxy and carboxylic acid groups, supporting robust coupling chemistry.
Reactivity: The carboxylic acid enables standard PROTAC linker conjugation via amide or ester-forming reactions with appropriate activated carboxyl derivatives. Typical approaches include activation using peptide-coupling reagents under mild base conditions, followed by reaction with amine-containing partners to form stable amide bonds. Solvents such as polar aprotic media are commonly used to promote coupling efficiency, while protecting-group strategies may be applied to preserve sensitive functional groups during synthesis.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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