I-PEG6-OH
CAS No.: 136399-07-0
Cat No.: BP-501519
4.5 
I-PEG6-OH is a heterobifunctional oligo(ethylene glycol) linker bearing a terminal iodide and a terminal hydroxyl group across a six–ethylene glycol unit PEG chain. Structurally, it provides a flexible, hydrophilic spacer that can be used to connect or tune the relative positioning of PROTAC “warhead” ligands and the E3 ligase–recruiting moiety. In targeted protein degradation designs, PEG-based linkers are widely employed to mitigate steric clashes, improve solubility, and allow the conjugated ligands to adopt productive orientations for ternary complex formation. The terminal iodide can undergo nucleophilic substitution, while the hydroxyl enables straightforward derivatization (e.g., activation to form an ester or ether linkage) to incorporate the linker into larger PROTAC constructs. As a modular spacer, I-PEG6-OH is valuable for systematic linker optimization studies, helping researchers balance flexibility and effective reach while maintaining aqueous compatibility for biochemical and cell-based assays.
Structure of 136399-07-0
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This PEG-based linker, I-PEG6-OH, is designed to provide a hydrophilic, flexible spacer for PROTAC assembly, helping tune the spatial relationship between a target-binding ligand and an E3-recruiting moiety. Its ether-rich, polyethylene glycol character supports solubility and can reduce nonspecific hydrophobic interactions in linker-ligand conjugates. The subsequent points provide a detailed description of structure and practical reactivity considerations for constructing targeted protein degraders.
Structure: I-PEG6-OH is a polyethylene glycol chain terminated with a free hydroxyl group, featuring repeating ether linkages that confer conformational flexibility. The molecule is characterized by ether oxygen atoms capable of hydrogen bonding, and an overall polar, water-compatible profile that supports stable conjugate formation.
Reactivity: The terminal hydroxyl enables common PROTAC linker-conjugation strategies such as activation to form ester or ether intermediates, followed by coupling to carboxylate- or amine-functional groups on ligands. Typical approaches rely on standard hydroxyl-activation chemistry using coupling reagents and/or acid- or halide-activated derivatives, with polar aprotic solvents and inert atmosphere often used to minimize side reactions.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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