m-PEG11-azide
Cat No.: BP-501780
Purity: 98%
4.5 
m-PEG11-azide is a methoxy-terminated polyethylene glycol linker bearing an azide functional group, designed for modular conjugation in targeted protein degradation workflows. Structurally, it consists of a PEG chain of intermediate length with a terminal azide that serves as a chemical handle for bioorthogonal coupling, most commonly via copper-free azide–alkyne cycloaddition (for example, with propargylated ligands) or related azide reactivity strategies. In PROTAC construction, this linker helps spatially separate the two recognition elements, tuning effective reach and relative orientation to promote formation of a productive ternary complex between the target-binding ligand and the E3 ligase ligand. The PEG segment also contributes to solubility and reduced nonspecific hydrophobic interactions, which can improve degradation performance and experimental handling. As a versatile PEG–azide building block, it is valuable for rapid linker optimization, enabling systematic variation of linker length and attachment chemistry to support mechanistic and structure–activity studies in targeted degradation research.
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* For research and manufacturing use only. Not for human or clinical use.
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m-PEG11-azide is a polyethylene glycol-based azide linker designed for modular assembly of PROTACs through bioorthogonal conjugation. Its PEG-rich scaffold improves solubility and provides a flexible spacer that can help tune the effective distance and orientation between the target-binding ligand and the E3 ligase recruiter. The azide handle enables efficient click-type coupling under mild conditions, supporting streamlined synthesis of targeted protein degradation constructs. Detailed structural and reactivity considerations are provided below.
Structure: The linker comprises a methoxy-terminated, meta-substituted PEG chain bearing a terminal azide functionality. It features ether linkages typical of PEG backbones, with an azide group suitable for selective cycloaddition. The resulting polymer-like character generally imparts hydrophilicity and conformational flexibility.
Reactivity: The azide group participates in copper-catalyzed azide–alkyne cycloaddition or related strain-promoted azide–alkyne chemistry, enabling attachment to alkyne-functional partners used in PROTAC synthesis. Typical coupling relies on mild, aqueous or mixed-solvent conditions compatible with sensitive ligands; copper-free variants are often selected to reduce metal-related side reactions. Reaction performance is governed by reagent stoichiometry, solvent composition, and ligand stability during conjugation.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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