m-PEG25-Hydrazide
Cat No.: BP-502061
4.5 
m-PEG25-Hydrazide is a methoxy-terminated polyethylene glycol (PEG) linker terminated with a hydrazide functional group, providing a flexible, water-compatible spacer of extended chain length suitable for bioconjugation workflows. In PROTAC and related targeted protein degradation constructs, PEG linkers are commonly used to tune the effective distance and relative orientation between the ligand warhead and the E3-recruiting or binding moiety, thereby improving productive ternary complex formation and reducing steric clashes. The hydrazide terminus enables covalent attachment to complementary carbonyl-containing partners (for example, via hydrazone formation under appropriate conditions) or other hydrazide-reactive handles, allowing modular assembly of multifunctional degraders. This product is valuable for researchers seeking to systematically vary linker length and polarity to optimize degradation potency, cooperativity, and solubility in vitro, while maintaining chemical handles for controlled conjugation and downstream analytical characterization.
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* For research and manufacturing use only. Not for human or clinical use.
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m-PEG25-Hydrazide is a polyethylene glycol (PEG)-based linker designed to support PROTAC assembly by providing a hydrophilic, flexible spacer and a hydrazide handle for chemoselective conjugation. Its PEG character can improve solubility and reduce nonspecific interactions, while the hydrazide functionality enables robust attachment to electrophilic partners commonly used in targeted protein degradation workflows. The detailed structural and reactivity considerations are provided below.
Structure: The linker consists of a PEG ether backbone terminated by a meta-positioned hydrazide group. It features repeating ethylene glycol units connected through ether linkages, with a terminal hydrazide (–NH–NH–C(O)–) capable of hydrogen bonding. The overall structure is flexible, highly solvated, and typically water-compatible.
Reactivity: The hydrazide moiety is suited for condensation-based conjugations with carbonyl-containing electrophiles, including aldehydes and activated carboxy derivatives, forming hydrazone or related linkage architectures used in PROTAC synthesis. Practical coupling is commonly performed under mild, aqueous/organic mixed conditions with pH control to favor the desired condensation while suppressing hydrolysis. Catalysts are not always required, but acid or base catalysis may be used depending on the electrophile and stability of intermediates.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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