Mal-PEG2-OH
CAS No.: 34321-81-8
Cat No.: BP-501526
Purity: ≥95%
4.5 
Mal-PEG2-OH is a short, heterobifunctional PEG-based linker bearing a terminal maleimide (Mal) for selective thiol conjugation and a terminal hydroxyl (OH) that provides a defined, hydrophilic spacer. Structurally, it comprises a two–ethylene glycol unit PEG segment that separates the reactive maleimide from the attachment point, minimizing steric interference and improving aqueous solubility of conjugates. In PROTAC design and targeted degradation workflows, Mal-PEG2-OH is used to connect a cysteine- or thiol-containing ligand (or a thiol introduced via engineered cysteine residues or reducing agents) to another PROTAC module, enabling controlled formation of stable thioether linkages through the maleimide–thiol reaction. Its compact PEG length supports efficient ternary complex formation while reducing nonspecific hydrophobic interactions. This linker is valuable for constructing modular, water-compatible PROTACs and for optimizing conjugation chemistry in experiments requiring reproducible, site-specific attachment.
Structure of 34321-81-8
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Mal-PEG2-OH is a PEG-based maleimide linker designed for efficient conjugation in PROTAC workflows, enabling the installation of a stable tether between a ligand and a recruiter-binding moiety. Its maleimide functionality supports selective coupling to thiol-containing partners, while the polyethylene glycol segment improves solubility and can help tune linker flexibility and effective intramolecular proximity. The detailed Structure and Reactivity characteristics are provided below.
Structure: Mal-PEG2-OH is a maleimide-containing polyethylene glycol derivative featuring a thio-Michael acceptor (maleimide) and a terminal hydroxyl group. The molecule contains an unsaturated cyclic imide core linked to an ether-rich PEG chain, providing a polar, water-compatible scaffold with multiple hydrogen-bonding sites.
Reactivity: The maleimide group undergoes thiol–maleimide conjugation via a Michael addition under mildly basic conditions, typically using thiol-containing ligands or cysteine-bearing intermediates. Reactions are commonly performed in aqueous or mixed aqueous/organic solvents to maintain solubility, with careful control of pH and thiol stoichiometry to favor selective adduct formation. No transition-metal catalyst is generally required for the coupling step.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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