Methyltetrazine-PEG25-acid
Cat No.: BP-501802
4.5 
Methyltetrazine-PEG25-acid is a heterobifunctional PROTAC linker built around a methyltetrazine reactive handle conjugated to a long, water-soluble PEG chain terminating in a carboxylic acid. The methyltetrazine moiety is designed for bioorthogonal inverse-electron-demand Diels–Alder ligation, enabling rapid coupling to complementary strained dienophiles (commonly trans-cyclooctenes) under mild conditions, which is widely used to assemble targeted degradation constructs with minimal perturbation of binding elements. The extended PEG spacer provides conformational flexibility and reduces steric interference between the warhead (e.g., ligand for an E3 ligase) and the target-binding ligand, improving the probability of productive ternary complex formation. As a carboxylic-acid functional group, it supports downstream amide or ester coupling to introduce the linker into larger PROTAC architectures. This linker is valuable for researchers optimizing linker length, solubility, and assembly efficiency in targeted protein degradation studies.
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* For research and manufacturing use only. Not for human or clinical use.
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Methyltetrazine-PEG25-acid is a PEG-based PROTAC linker engineered for efficient conjugation chemistry and reliable handling in bioconjugation workflows. Its methyltetrazine motif enables rapid, selective bioorthogonal coupling, while the PEG spacer provides favorable solubility and conformational flexibility for modular conjugation workflows. This product is well suited for constructing targeted protein degraders by connecting a ligand scaffold to an E3-recruiting or binding partner. Detailed structural and reactivity considerations are provided below.
Structure: The linker combines a methyltetrazine functional group with a long polyethylene glycol chain terminated by a carboxylic acid. The scaffold contains heteroaromatic nitrogen-rich functionality, ether linkages within the PEG, and a terminal carboxyl group for derivatization. Overall polarity and hydrogen-bonding capacity support aqueous compatibility.
Reactivity: Methyltetrazine participates in tetrazine–dienophile bioorthogonal ligation, typically performed under mild, aqueous-compatible conditions to preserve sensitive ligands. Conjugation is commonly executed using strained dienophiles such as trans-cyclooctene (TCO) or selected strained alkynes as reaction partners for the tetrazine. For carboxylic-acid utilization, standard amide or ester coupling strategies can be applied with activating reagents and base in suitable solvents, followed by purification to remove excess coupling reagents.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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