Bis-PEG25-TFP ester
Cat No.: BP-501832
4.5 
Bis-PEG25-TFP ester is a bifunctional, PEG-based linker featuring two terminal tetrafluorophenyl (TFP) activated ester groups designed for robust amide-bond formation with primary amines on PROTAC-relevant ligands. Structurally, the molecule comprises two long polyethylene glycol chains that provide aqueous solubility and molecular spacing, while the activated ester handles serve as electrophilic conjugation sites for coupling to amine-bearing warheads or targeting moieties. In PROTAC architectures, such linkers are used to connect two functional components while tuning effective distance, flexibility, and local concentration at the ternary complex interface, thereby supporting productive recruitment of the target protein and E3 ligase partners. The PEG spacer can also help reduce nonspecific hydrophobic interactions and improve handling of bulky conjugates. This product is valuable for researchers optimizing linker length and coupling chemistry to generate consistent, well-defined PROTAC conjugates for targeted protein degradation studies.
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* For research and manufacturing use only. Not for human or clinical use.
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Bis-PEG25-TFP ester is a bifunctional, PEG-based linker engineered for PROTAC assembly, enabling efficient conjugation of two targeting ligands through activated carboxylate chemistry. Its long, flexible polymer backbone promotes productive spatial organization between the ligand moieties and can help tune solubility and conformational freedom in degradation constructs. The TFP ester functionality supports robust coupling workflows, and the linker is well suited for researchers seeking reproducible synthesis of targeted protein degraders; detailed structural and reactivity considerations are provided below.
Structure: The molecule comprises two polyethylene glycol segments connected to a central bis-activated motif bearing TFP ester groups. It contains ester linkages and ether-rich PEG chains, providing high polarity, flexibility, and favorable aqueous compatibility. The bifunctional design supports sequential or orthogonal ligand installation via the reactive ester sites.
Reactivity: TFP esters react with primary amines and related nucleophiles under mild base conditions to form stable amide bonds, commonly via acyl substitution. Typical coupling employs anhydrous or low-water organic solvents with controlled pH, followed by purification to remove byproducts. No special catalysts are generally required beyond base activation; careful stoichiometry and temperature control help minimize hydrolysis and preserve linker integrity during PROTAC synthesis.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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