Name: mPEG10-acetic acid
Brand: BOC Sciences
Rating: 5 (1 reviews)

Size

Price

Stock

Quantity

$--

In stock

Purity

95%

Storage

Pure form, -20°C, 3 years; 4°C, 2 years; In solvent, -80°C, 6 months; -20°C, 1 month

Shipping

Room temperature in continental US; may vary elsewhere.

IUPACName

2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]acetic acid

Synonyms

mPEG10-CH2COOH; 2,5,8,11,14,17,20,23,26,29,32-Undecaoxatetratriacontan-34-oic acid

Boiling Point

588.5±45.0 °C at 760 mmHg

Density

1.122

InChI Key

DNJQYLLQMMESPG-UHFFFAOYSA-N

InChI

InChI=1S/C23H46O13/c1-26-2-3-27-4-5-28-6-7-29-8-9-30-10-11-31-12-13-32-14-15-33-16-17-34-18-19-35-20-21-36-22-23(24)25/h2-22H2,1H3,(H,24,25)

SMILES

COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCC(=O)O

1.[Effects of beta glucan in highland barley on blood glucose and serum lipid in high fat-induced C57 mouse].

Tian MJ1, Song JN, Liu PP, Su LH, Sun CH, Li Y. Zhonghua Yu Fang Yi Xue Za Zhi. 2013 Jan;47(1):55-8.

OBJECTIVE: Study the effects of β-glucan in highland barley on blood glucose and serum lipid in high fat diet induced C57 mouse.

2.Panobinostat plus bortezomib and dexamethasone versus placebo plus bortezomib and dexamethasone in patients with relapsed or relapsed and refractory multiple myeloma: a multicentre, randomised, double-blind phase 3 trial.

San-Miguel JF1, Hungria VT2, Yoon SS3, Beksac M4, Dimopoulos MA5, Elghandour A6, Jedrzejczak WW7, Günther A8, Nakorn TN9, Siritanaratkul N10, Corradini P11, Chuncharunee S12, Lee JJ13, Schlossman RL14, Shelekhova T15, Yong K16, Tan D17, Numbenjapon T18, Cavenagh JD19, Hou J20, LeBlanc R21, Nahi H22, Qiu L23, Salwender H24, Pulini S25, Moreau P26, Warzocha K27, White D28, Bladé J29, Chen W30, de la Rubia J31, Gimsing P32, Lonial S33, Kaufman JL33, Ocio EM34, Veskovski L35, Sohn SK36, Wang MC37, Lee JH38, Einsele H39, Sopala M40, Corrado C40, Bengoudifa BR40, Binlich F41, Richardson PG14. Lancet Oncol. 2014 Oct;15(11):1195-206. doi: 10.1016/S1470-2045(14)70440-1. Epub 2014 Sep 18.

BACKGROUND: Panobinostat is a potent oral pan-deacetylase inhibitor that in preclinical studies has synergistic anti-myeloma activity when combined with bortezomib and dexamethasone. We aimed to compare panobinostat, bortezomib, and dexamethasone with placebo, bortezomib, and dexamethasone in patients with relapsed or relapsed and refractory multiple myeloma.

3.HPLC-UV-MS profiles of phenolic compounds and antioxidant activity of fruits from three citrus species consumed in Northern Chile.

Brito A1, Ramirez JE2, Areche C3, Sepúlveda B4, Simirgiotis MJ5. Molecules. 2014 Oct 29;19(11):17400-21. doi: 10.3390/molecules191117400.

Peels and edible pulp from three species of citrus including Citrus aurantifolia (varieties pica and sutil) and Citrus x lemon var. Genova widely cultivated and consumed in Northern Chile (I and II region) were analyzed for phenolic compounds and antioxidant activity for the first time. A high performance electrospray ionization mass spectrometry (HPLC-UV-ESI-MS) method was developed for the rapid identification of phenolics in extracts from peels and juices of all species. Several flavonoids including one kaempferol-O-hexoside (peak 16) and one hesperidin derivative (peak 22) three quercetin derivatives (peaks 4, 19 and 36), five isorhamnetin derivatives (peaks 5, 23, 24, 26 and 29) four luteolin derivatives (peaks 14, 25, 27 and 40), seven apigenin derivatives (peaks 2, 3, 12, 20, 34, 35 and 39), seven diosmetin derivatives (peaks 7-9, 17, 21, 31 and 37), three chrysoeriol derivatives (peaks 10, 18 and 30), and four eryodictiol derivatives (peaks 6, 13, 15 and 38) were identified in negative and positive mode using full scan mass measurements and MSn fragmentations.

mPEG10-acetic acid is an mPEG-based acetic acid linker designed to support PROTAC and related targeted protein degradation workflows by providing a hydrophilic, sterically tunable handle for conjugation to ligands. Its ether-rich polyethylene glycol segment can improve solubility and bioconjugation compatibility, while the terminal carboxylic acid enables reliable coupling strategies to assemble bifunctional degraders. The subsequent points describe its structural features and practical reactivity considerations in detail below.

Structure: This linker consists of a methoxy-terminated poly(ethylene glycol) chain capped with a carboxylic acid group. It contains repeating ether linkages along a flexible backbone, with a terminal aliphatic acetic acid functionality. The resulting amphiphilic character supports aqueous compatibility and stable covalent derivatization.

Reactivity: The carboxylic acid end group is typically activated for amide-bond formation using standard coupling chemistries such as carbodiimide-based reagents or activated ester approaches. For PROTAC assembly, the activated acid can react with primary amines on target- or E3-ligand moieties under mild conditions to form stable amide linkages. Commonly used solvents include polar aprotic media, and reaction progress is monitored by standard analytical methods to ensure efficient conjugation while minimizing side reactions.

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* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C₁V₁ = C₂V₂