mPEG11-bromide
CAS No.: 1258596-39-2
Cat No.: BP-501678
Purity: >95%
4.5 
mPEG11-bromide is a methoxy-terminated poly(ethylene glycol) bromide that serves as a reactive PEG linker for constructing PROTACs and other targeted conjugates. Structurally, it consists of a linear PEG chain capped with a terminal methoxy group and a bromine leaving group, enabling efficient nucleophilic substitution to install the PEG segment onto amine, thiol, or other nucleophile-bearing building blocks. In PROTAC design, this PEG spacer can be used to tune linker length, enhance solubility, and reduce nonspecific hydrophobic interactions, thereby improving the effective presentation and accessibility of the two ligands that recruit an E3 ligase and the target protein. By providing a hydrophilic, flexible tether, mPEG11-bromide helps modulate the spatial relationship between conjugated components, which is critical for productive ternary complex formation. This reagent is valuable for researchers optimizing linker architecture and physicochemical properties during targeted protein degradation experiments.
Structure of 1258596-39-2
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This mPEG11-bromide is an activated methoxy poly(ethylene glycol) bromide linker designed for efficient installation of PEG chains onto nucleophilic partners during PROTAC assembly. Its ether-rich, flexible scaffold can enhance solubility and tune linker length/spacing to support productive ternary-complex formation. The bromide leaving group enables straightforward functionalization under standard organic synthesis conditions, and the resulting PEGylated intermediates are commonly used to generate PROTAC conjugates; detailed structure and reactivity guidance follows below.
Structure: The linker is a methoxy-terminated poly(ethylene glycol) chain bearing a terminal bromide, providing a flexible, ether-dominated backbone. It contains repeating C–O ether bonds and a carbon–bromine bond at the activation site, yielding a polar, hydrophilic PEG segment suitable for aqueous-compatible bioconjugation chemistry.
Reactivity: The terminal bromide participates in nucleophilic substitution to form C–X or C–O/C–N linkages, depending on the nucleophile used. PROTAC-relevant conjugation is typically achieved by reacting the bromide with suitable nucleophiles (e.g., amines or alcohol/thiol derivatives) under base-promoted conditions. Common solvents include polar aprotic media, and reaction progress is monitored by standard analytical methods; mild temperatures are often used to preserve sensitive functional groups.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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