mPEG4-aldehyde
CAS No.: 197513-96-5
Cat No.: BP-501413
Purity: >95%
4.5 
mPEG4-aldehyde is a short-chain methoxy-poly(ethylene glycol) aldehyde reagent featuring a terminal aldehyde suitable for chemoselective conjugation. Structurally, it provides an ether-based PEG segment that confers aqueous solubility and can modulate steric and hydrophilic properties of PROTAC intermediates, while the aldehyde group can form reversible imines with primary amines and stable amine products after reductive amination, or oxime/hydrazone linkages with aminooxy/hydrazide partners. In targeted protein degradation design, PEG aldehydes are commonly used to introduce a hydrophilic spacer between functional domains, improving dispersion and reducing aggregation of bulky ligands, and enabling controlled attachment of E3-ligase-binding or linker elements during PROTAC assembly. This reagent is valuable for researchers optimizing linker length, solubility, and conjugation efficiency in iterative PROTAC synthesis and characterization, supporting reproducible preparation of degraders for biochemical and cellular evaluation.
Structure of 197513-96-5
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mPEG4-aldehyde is a polyethylene glycol (mPEG) functionalized aldehyde designed for site-selective conjugation steps commonly used in PROTAC linker assembly and related bifunctional construct preparation. Its aldehyde handle enables controlled coupling to nucleophilic partners, supporting modular synthesis workflows and improved solubility or handling of PROTAC intermediates. The structure, reactivity, and practical considerations are described in detail below.
Structure: mPEG4-aldehyde consists of an mPEG chain terminating in a reactive aldehyde group. The linker contains an ether-rich PEG backbone with a terminal carbonyl, providing flexibility, hydrophilicity, and a chemically distinct electrophilic site suitable for condensation or nucleophilic addition.
Reactivity: The aldehyde group can undergo nucleophilic addition and reversible condensation with amines or hydrazides, enabling formation of imines or hydrazones under mild conditions. Typical PROTAC-linker construction uses appropriate nucleophiles, controlled pH, and dry, compatible solvents to limit aldehyde side reactions such as self-condensation. Catalysts such as mild acids are sometimes used to accelerate imine/hydrazone formation, while subsequent reduction or stabilization can be applied depending on the desired linkage stability.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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