mPEG7-alcohol

mPEG7-alcohol is a methoxy-terminated polyethylene glycol (PEG) linker alcohol designed to support PROTAC synthesis and related targeted protein degradation workflows. Its PEG backbone provides hydrophilicity and conformational flexibility, which can improve solubility and facilitate the modular assembly of bifunctional degraders. The terminal alcohol functionality enables reliable conjugation strategies to install warheads or ligands, and the product is commonly used as a PEG spacer to tune linker length and physicochemical behavior. Detailed structural and reactivity considerations are provided below.

Structure: mPEG7-alcohol is a methoxy-capped PEG chain terminating in a primary alcohol. It contains repeating ether (C–O–C) units along a flexible polyether backbone, with a terminal hydroxyl group for derivatization. The ether-rich structure confers strong hydrogen-bonding capacity and high hydrophilicity.

Reactivity: The terminal alcohol can be converted into activated intermediates for PROTAC assembly via standard alcohol-derivatization chemistry, such as esterification or ether formation with electrophilic coupling partners. Typical approaches include using carboxylic acid derivatives or activated halides under base catalysis, or employing coupling reagents compatible with PEG alcohols. Mild, anhydrous conditions and PEG-stable solvents (e.g., polar aprotic media) are generally preferred to minimize side reactions and preserve linker integrity.