mPEG8-propyne
CAS No.: 880081-81-2
Cat No.: BP-501702
Purity: >98%
4.5 
mPEG8-propyne is an mPEG-based propargyl (propyne) linker reagent featuring a methoxy-terminated polyethylene glycol chain of approximately eight ethylene oxide units and a terminal alkyne for chemical “click” conjugation. Structurally, it provides a flexible, hydrophilic spacer that can be appended to PROTAC-related ligands or scaffolds to tune solubility, reduce nonspecific interactions, and improve handling in aqueous degradation assays. In targeted protein degradation workflows, the terminal alkyne enables efficient bioorthogonal coupling (commonly via Cu(I)-catalyzed azide–alkyne cycloaddition (CuAAC)), allowing researchers to connect this PEG module to complementary azide-bearing components such as warhead ligands, E3 ligase recruiters, or reporter tags. Its value lies in offering a modular, chemically robust handle for assembling degraders with controlled linker length and physicochemical properties, facilitating systematic structure–activity studies and optimization of ternary complex formation and cellular activity.
Structure of 880081-81-2
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mPEG8-propyne is a polyethylene glycol–based propargyl ether linker designed to support efficient conjugation steps commonly used in PROTAC assembly workflows. Its PEG-rich scaffold provides aqueous compatibility and can help modulate solubility and handling during linker installation, while the terminal alkyne enables bioorthogonal coupling strategies. The combination of a hydrophilic mPEG segment with a reactive propargyl handle makes it a practical intermediate for constructing targeted protein degradation constructs. Detailed structural and reactivity considerations are provided below.
Structure: The molecule consists of an mPEG chain terminated with a propargyl (alkyne) functionality. It contains ether linkages within the PEG backbone and a terminal carbon–carbon triple bond suitable for click-type reactions. The PEG segment imparts strong hydrophilicity and flexible conformational behavior in solution.
Reactivity: The terminal alkyne is well suited for copper(I)-catalyzed azide–alkyne cycloaddition or related alkyne–azide coupling approaches used to connect PROTAC components. Typical conditions employ a Cu(I) source generated in situ, an appropriate solvent compatible with PEG conjugates, and inert atmosphere or oxygen-managed setups to preserve catalyst activity. Reaction proceeds via formation of a copper–acetylide intermediate followed by cycloaddition to the azide partner.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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