MRTX849 acid - CAS 2561529-96-0

MRTX849 acid is a derivative of MRTX849. MRTX849 is a potent and mutation-selective covalent inhibitor of KRAS G12C. It maximizes inhibition by irreversibly locking the KRAS molecule in its inactive state, thereby preventing tumor cell growth which results in tumor cell death.

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Molecular Formula
C34H37ClFN7O4
Molecular Weight
662.2
    • Specification
      • Purity
        98% by HPLC
        Appearance
        Light Yellow to Yellow Solid
        IUPAC Name
        3-[(2S)-2-[[7-(8-chloronaphthalen-1-yl)-4-[(3S)-3-(cyanomethyl)-4-(2-fluoroprop-2-enoyl)piperazin-1-yl]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-2-yl]oxymethyl]pyrrolidin-1-yl]propanoic acid
    • Properties
      • InChI Key
        CWTHNCSWSDACRS-DQEYMECFSA-N
        InChI
        InChI=1S/C34H37ClFN7O4/c1-22(36)33(46)43-18-17-42(19-24(43)10-13-37)32-26-11-15-41(29-9-3-6-23-5-2-8-27(35)31(23)29)20-28(26)38-34(39-32)47-21-25-7-4-14-40(25)16-12-30(44)45/h2-3,5-6,8-9,24-25H,1,4,7,10-12,14-21H2,(H,44,45)/t24-,25-/m0/s1
        Canonical SMILES
        C=C(C(=O)N1CCN(CC1CC#N)C2=NC(=NC3=C2CCN(C3)C4=CC=CC5=C4C(=CC=C5)Cl)OCC6CCCN6CCC(=O)O)F
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L

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Tip: Chemical formula is case sensitive. C22H30N4O c22h30n40
g/mol
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