Mal-amido-PEG8-TFP ester

 CAS No.: 1924596-31-5  Cat No.: BP-501442  Purity: ≥95% 4.5  

Mal-amido-PEG8-TFP ester is a PEG linker containing a maleimide and TFP ester end group. The Maleimide group is reactive with thiols between pH 6.5 and 7.5. The TFP ester can react with primary amine groups and is also less susceptible to undergo hydrolysis compared to NHS ester. The hydrophilic PEG chain increases the water solubility of a compound in aqueous media.

Mal-amido-PEG8-TFP ester

Structure of 1924596-31-5

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PROTAC Linker
Molecular Formula
C32H44F4N2O13
Molecular Weight
740.69

* For research and manufacturing use only. Not for human or clinical use.

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Purity
≥95%
Solubility
Soluble in DMSO
Storage
Store at 2-8°C for short term (days to weeks) or -20°C for long term (months to years)
Shipping
Room temperature in continental US; may vary elsewhere.
IUPACName
(2,3,5,6-tetrafluorophenyl) 3-[2-[2-[2-[2-[2-[2-[2-[2-[3-(2,5-dioxopyrrol-1-yl)propanoylamino]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate
Synonyms
Mal-NH-PEG8-TFP; MAL-PEG8-TFP ester; MAL-dPEG8-TFP ester; 2,3,5,6-Tetrafluorophenyl 31-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-29-oxo-4,7,10,13,16,19,22,25-octaoxa-28-azahentriacontan-1-oate; 4,7,10,13,16,19,22,25-Octaoxa-28-azahentriacontanoic acid, 31-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-29-oxo-, 2,3,5,6-tetrafluorophenyl ester; 2,3,5,6-tetrafluorophenyl 1-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3-oxo-7,10,13,16,19,22,25,28-octaoxa-4-azahentriacontan-31-oate
Boiling Point
780.6±60.0°C at 760 mmHg
Density
1.3±0.1 g/cm3
InChI Key
YQFZOPSEPCSFQQ-UHFFFAOYSA-N
InChI
InChI=1S/C32H44F4N2O13/c33-24-23-25(34)31(36)32(30(24)35)51-29(42)4-7-43-9-11-45-13-15-47-17-19-49-21-22-50-20-18-48-16-14-46-12-10-44-8-5-37-26(39)3-6-38-27(40)1-2-28(38)41/h1-2,23H,3-22H2,(H,37,39)
Canonical SMILES
C1=CC(=O)N(C1=O)CCC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)OC2=C(C(=CC(=C2F)F)F)F

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L

* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2

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* Total Molecular Weight:
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Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
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Historical Records: m-PEG11-Hydrazide | Acid-PEG3-t-butyl ester | DBCO-NHCO-PEG2-amine | N-Me-N-bis(PEG4-C2-Boc) | N-(m-PEG4)-3,3-Dimethyl-3H-indole-N'-(acid-PEG3)-benzothiazole | Bis-MAL-PEG4-PEG12-Lysine-Tris(mPEG24)3 | N-methyl-N'-methyl-O-(m-PEG4)-O'-(acid-PEG5)-Cy5 | N-Boc-1,4-butanediamine | Methyltetrazine-PEG8-N3 | t-Butyl acetate-PEG3-CH2COOH | Mal-amido-PEG8-TFP ester

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