N-(Hydroxy-PEG3)-N-bis(PEG4-Boc)
CAS No.: 2112734-70-8
Cat No.: BP-501304
4.5 
N-(Hydroxy-PEG3)-N-bis(PEG4-Boc) is a polyethylene glycol–based PROTAC linker building block featuring one hydroxyl-terminated PEG3 arm and two PEG4 arms bearing tert-butyl ester-protected carboxylic acid termini around a central tertiary amine. The PEG chains provide a hydrophilic, flexible spacer that can reduce steric interference and improve effective reach between a ligand that recruits an E3 ligase and a ligand that binds the target protein. In PROTAC architectures, such linkers are used to tune the relative positioning and conformational freedom of the two binding domains, thereby supporting formation of a productive ternary complex and efficient ubiquitination-driven degradation. The tert-butyl esters can be removed to reveal two carboxylic acids for controlled post-assembly functionalization, enabling attachment to complementary reactive handles on other PROTAC components. This product is valuable for researchers optimizing linker length, polarity, and attachment chemistry in targeted protein degradation studies.
Structure of 2112734-70-8
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* For research and manufacturing use only. Not for human or clinical use.
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This PROTAC linker reagent is designed to provide a polyethylene glycol (PEG)-based hydrophilic spacer platform that enhances solubility and can improve the conformational flexibility of ternary-complex forming molecules. Its tert-butyl ester-protected carboxyl groups enable controlled, stepwise installation of attachment handles for coupling to ligand scaffolds used in targeted protein degradation. The structure and reactivity features that support reliable PROTAC assembly are described in detail below.
Structure: The molecule is a PEGylated, multifunctional linker bearing a terminal hydroxy group and multiple PEG ether segments, with two tert-butyl ester-protected carboxylic acid functionalities. It contains ether linkages characteristic of PEG chains and tert-butyl ester groups protecting carboxylic acids, contributing to aqueous compatibility and controlled reactivity.
Reactivity: The tert-butyl esters are typically cleaved under acidic conditions to reveal carboxylic acids for subsequent coupling. The terminal hydroxy group can be leveraged for esterification or ether-forming strategies using activated carboxylic acid derivatives or appropriate electrophiles. PROTAC synthesis commonly proceeds via sequential deprotection followed by amide-bond formation, using standard coupling reagents and polar organic solvents to maintain PEG solubility and minimize side reactions.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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