N3-PEG6-Propanehydrazide
Cat No.: BP-502082
4.5 
N3-PEG6-Propanehydrazide is a heterobifunctional polyethylene glycol (PEG) linker featuring a terminal hydrazide group and an N3-functional handle suitable for conjugation to PROTAC-related ligands. Structurally, it comprises an approximately six-unit PEG chain that provides aqueous solubility and conformational flexibility, together with a hydrazide moiety capable of forming stable hydrazone linkages with carbonyl-containing partners or participating in hydrazide-based coupling strategies used in targeted protein degradation workflows. In PROTAC design, PEG linkers are widely employed to tune the effective distance and relative orientation between the target-binding ligand and the E3-recruiting ligand, thereby improving productive ternary complex formation and degradation efficiency. This reagent is valuable for constructing modular degradation probes and PROTACs under research conditions, enabling systematic linker-length and attachment-site optimization while maintaining compatibility with common conjugation chemistries used to assemble degraders for mechanistic and structure–activity studies.
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* For research and manufacturing use only. Not for human or clinical use.
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N3-PEG6-Propanehydrazide is a PEG-based PROTAC linker designed to provide conformational flexibility and aqueous compatibility while presenting a hydrazide handle for controlled conjugation. Its ether-rich scaffold helps decouple the binding elements, supporting efficient ternary-complex formation in targeted protein degradation workflows. The hydrazide functionality enables practical coupling strategies for assembling degraders, and the molecule will be described in detail below.
Structure: The linker consists of a polyethylene glycol chain terminating in a propanehydrazide moiety, featuring ether linkages along the PEG backbone and an amide/ hydrazide functional group. It contains multiple hydrogen-bonding sites that enhance solubility and can support favorable linker–protein and linker–ligand interactions.
Reactivity: The terminal hydrazide can participate in hydrazone formation with aldehydes or ketones under mildly acidic conditions, enabling reversible linkage strategies often used in PROTAC assembly. Alternatively, hydrazide-derived coupling can proceed via acyl-activation approaches to form stable amide bonds with appropriately functionalized partners. Typical conditions employ polar organic solvents or aqueous/organic mixtures, with acid catalysts for condensation when hydrazone chemistry is selected.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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