NH-bis-PEG3
CAS No.: 25743-12-8
Cat No.: BP-501420
4.5 
NH-bis-PEG3 is a branched amino-diol polyethylene glycol scaffold featuring a central secondary amine and two terminal hydroxyl groups connected through PEG3 segments. The PEG ether backbone provides a hydrophilic, flexible spacer that can reduce steric clashes between the ligand-binding moieties and improve the effective reach and orientation required for ternary complex formation. In PROTAC architectures, this type of linker mediates conjugation by coupling to the functional groups of two partners—typically a target-recruiting ligand and an E3 ligase ligand—while maintaining sufficient conformational freedom for productive proximity. The central amine can be acylated or alkylated, while the terminal alcohols require activation before further derivatization, enabling researchers to generate defined, modular degraders with tunable linker length and polarity. As a practical PEG-based spacer, NH-bis-PEG3 is valuable for optimizing degradation potency and selectivity by balancing solubility, linker flexibility, and spatial arrangement of the interacting components.
Structure of 25743-12-8
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NH-bis-PEG3 is a polyethylene glycol (PEG)-based bifunctional linker designed for constructing PROTACs and related targeted protein degradation conjugates. Its flexible ether-rich scaffold can help tune linker length, solubility, and conformational behavior, supporting productive ternary-complex formation between a target ligand and an E3 ligase binder. The structure and reactivity considerations for PROTAC synthesis and conjugation are described in detail below.
Structure: NH-bis-PEG3 is a bifunctional PEG linker featuring a central secondary amine, two terminal hydroxyl groups, and ether linkages along a flexible polyether chain. The presence of multiple oxygen atoms promotes hydrophilicity, while the central secondary amine can undergo acylation and the terminal alcohols provide additional derivatization sites.
Reactivity: The central secondary amine is suitable for coupling to activated carboxylic-acid-bearing ligands, while the terminal alcohols can be esterified or converted to leaving groups for additional functionalization. Common approaches include carbodiimide-mediated activation with appropriate additives, or alternative coupling reagents that form reactive esters in situ. Solvent systems that support both solubility and coupling efficiency, along with mild base conditions, are typically used to preserve sensitive functional groups and maintain linker integrity during PROTAC assembly.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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