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NRX-252114 - CAS 2763260-39-3

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NRX-252114 is a potent enhancer of the interaction between β-catenin and its cognate E3 ligase, SCF-TrCP. It enhances the binding of pSer33/S37A β-catenin peptide to -TrCP with an EC50 of 6.5 nM and a Kd of 0.4 nM. NRX-252114 induces degradation of mutant β-catenin.

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Molecular Formula
C22H12Cl2F3N3O2S
Molecular Weight
510.32

NRX-252114

    • Specification
      • Appearance
        Solid
        Storage
        Store at -20°C
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