Propargyl-PEG12-methane
Cat No.: BP-502107
4.5 
Propargyl-PEG12-methane is a PEG-based linker bearing a terminal propargyl (alkyne) functionality connected through a short polymethylene spacer, providing a flexible, hydrophilic chain length suitable for PROTAC assembly. Structurally, the PEG segment acts as an extended, solvent-exposed tether that can reduce steric clashes between the two binding ligands of a PROTAC and help maintain productive geometry for recruitment of the target protein and the E3 ligase. The terminal alkyne enables chemoselective conjugation via copper-catalyzed azide–alkyne cycloaddition or related click-type strategies, allowing modular attachment to azide-functional warheads or ligase-binding moieties. In targeted protein degradation research, this linker is valuable for tuning linker length and flexibility to optimize ternary complex formation, degradation potency, and physicochemical properties such as solubility. Its modular handle supports efficient synthesis and systematic structure–activity studies in PROTAC development.
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* For research and manufacturing use only. Not for human or clinical use.
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Propargyl-PEG12-methane is a polyethylene glycol (PEG)-based linker designed to support PROTAC assembly by providing a flexible, hydrophilic spacer that can improve effective ternary complex formation and reduce non-specific interactions. Its terminal propargyl functionality enables bioorthogonal-style conjugation strategies, facilitating modular synthesis of targeted protein degraders. The following points describe the linker’s structural features and practical reactivity considerations for PROTAC construction in research workflows.
Structure: The linker comprises a PEG ether backbone terminated with a propargyl group, featuring repeating ethylene glycol units connected through ether linkages. It contains a terminal alkyne suitable for selective coupling, and a flexible, conformationally mobile chain that enhances solubility and reduces aggregation.
Reactivity: The propargyl terminus is typically used as an alkyne handle for coupling reactions that form stable carbon–carbon or heteroatom-containing linkages, depending on the partner warhead chemistry. In PROTAC synthesis, it is commonly incorporated under mild conditions using standard organic synthesis practices; solvent choice favors PEG solubility, and catalysts are selected according to the specific alkyne-reactive coupling method (e.g., alkyne-driven click-type transformations).
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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