PROTAC AR-V7 degrader-1

 CAS No.: 2767440-24-2  Cat No.: BP-400178 4.5  

PROTAC AR-V7 degrader-1 is an orally active selective AR-V7 degrader with a DC50 of 0.32 µM. It functions by recruiting the VHL E3 ligase to the androgen receptor DNA-binding domain (AR DBD). PROTAC AR-V7 degrader-1 is active against the 22Rv1 cell line expressing AR-V7, with an EC50 of 0.88 µM.

PROTAC AR-V7 degrader-1

Structure of 2767440-24-2

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PROTAC
Molecular Formula
C41H52N6O6S2
Molecular Weight
789.02
Appearance
Solid

* For research and manufacturing use only. Not for human or clinical use.

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Solubility
DMSO: 110 mg/mL (139.41 mM; Need ultrasonic)
Appearance
Solid
Storage
Store at -20°C, protect from light

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