S-Acetyl-PEG3-azide
CAS No.: 1310827-26-9
Cat No.: BP-501221
Purity: 98%
4.5 
S-Acetyl-PEG3-azide is a PEG-based linker featuring an azide functional group for bioorthogonal conjugation and an S-acetyl-protected thiol (thioacetate) handle that can participate in controlled coupling chemistry. Structurally, it consists of a short, three–ethylene glycol unit chain that provides aqueous solubility and conformational flexibility, while the azide enables efficient attachment to complementary alkyne-bearing partners via copper-free azide–alkyne cycloaddition or related click-compatible strategies. In PROTAC design, such linkers are commonly used to connect a targeting ligand to an E3 ligase ligand or to introduce a modular “attachment point” for subsequent functionalization, thereby tuning effective molarity and the spatial orientation required for productive ternary complex formation. Its PEG character can reduce nonspecific hydrophobic interactions and improve handling in aqueous experimental workflows. Overall, S-Acetyl-PEG3-azide is a practical building block for constructing and optimizing targeted protein degradation molecules with modular, reliable conjugation chemistry.
Structure of 1310827-26-9
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S-Acetyl-PEG3-azide is a PEG-based chemical linker designed for efficient incorporation into PROTAC architectures, enabling modular assembly of targeted protein degraders. Its azide functionality supports bioorthogonal conjugation strategies, while the S-acetyl thioester serves as a masked thiol and the PEG segment provides solubility and conformational flexibility. The following sections describe its structure and practical reactivity considerations for PROTAC construction in detail below.
Structure: The molecule comprises a PEG chain bearing an S-acetyl thioester at one end and an azide group at the other. It contains ether linkages within the PEG backbone, a thioester carbonyl from the S-acetyl group, and a terminal azide suitable for click-type transformations. The overall structure is polar and flexible, promoting aqueous compatibility.
Reactivity: The terminal azide is typically used in copper-catalyzed azide–alkyne cycloaddition or related azide conjugation workflows to connect PROTAC warheads and targeting ligands. The S-acetyl group can be deacetylated to reveal a free thiol for subsequent thiol-selective conjugation, while click reactions are performed under conditions compatible with the protected or liberated thiol as needed. Mechanistically, cycloaddition proceeds via azide activation and formation of a stable triazole linkage, enabling modular, high-yield assembly of degradation constructs.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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