t-Boc-N-amido-PEG7-amine
CAS No.: 206265-98-7
Cat No.: BP-500144
Purity: >98%
4.5 
t-Boc-N-amido-PEG7-amine is a polyethylene glycol–based amine building block featuring a terminal primary amine for subsequent coupling and a protected amide functionality, with a Boc (tert-butoxycarbonyl) group providing orthogonal control over reactivity during multistep synthesis. The PEG7 segment provides a flexible, hydrophilic spacer that can reduce steric interference and improve solubility of conjugates, while the amide linkage type supports stable conjugation chemistry compatible with common PROTAC assembly strategies. In PROTAC design, such linkers are used to connect a ligand for an E3 ligase to a target-binding moiety, tuning the effective distance and relative orientation required for productive ternary complex formation. Researchers value this class of PEG linkers for systematic optimization of degradation potency and selectivity, enabling reproducible synthesis of degraders and facilitating downstream functionalization under controlled protection/deprotection conditions.
Structure of 206265-98-7
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|---|---|---|---|
| -- | $-- | In stock |
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| ConcentrationVolumeMass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.1341 mL | 10.6705 mL | 21.3411 mL |
| 5 mM | 0.4268 mL | 2.1341 mL | 4.2682 mL |
| 10 mM | 0.2134 mL | 1.0671 mL | 2.1341 mL |
t-Boc-N-amido-PEG7-amine is a polyethylene glycol (PEG)-based PROTAC linker building block designed to connect ligands while providing conformational flexibility and improved solubility in typical organic reaction media. Its amide-containing tether and protected amine enable controlled coupling strategies that are widely used in targeted protein degradation workflows. The linker’s modular functionality supports systematic variation of linker length and attachment chemistry; detailed structural and reactivity considerations are provided below.
Structure: The linker comprises a PEG oligomer segment bearing an amide linkage and a terminal primary amine protected as a tert-butoxycarbonyl (t-Boc) carbamate. It contains ether oxygen atoms along the PEG chain, an amide carbonyl, and stable C–N and C–O bonds, yielding a polar, flexible scaffold suitable for bioconjugation-style assembly.
Reactivity: PROTAC construction commonly employs deprotection of the t-Boc group under acid-mediated conditions to reveal the free amine, followed by amide-forming coupling to activated carboxylic acid partners or to NHS/active ester derivatives. The amine can also participate in carbamate or urea-forming routes depending on the electrophile. Typical coupling relies on standard peptide-coupling reagents and compatible solvents, while preserving the PEG and amide integrity under mild conditions.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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