Name: t-Boc-N-amido-PEG9-alcohol
Brand: BOC Sciences
Rating: 5 (1 reviews)

Size

Price

Stock

Quantity

$--

In stock

Purity

≥95%

Solubility

Soluble in DCM, DMF, DMSO, Water

Appearance

Pale Yellow or Colorless Oily Matter

Storage

Store at 2-8°C

Shipping

Room temperature

IUPACName

tert-butyl N-[2-[2-[2-[2-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl]carbamate

Synonyms

NHBoc-PEG9-OH; N-Boc-PEG9-alcohol; BocNH-PEG9-OH; tert-Butyl (26-hydroxy-3,6,9,12,15,18,21,24-octaoxahexacosyl)carbamate; 5,8,11,14,17,20,23,26-Octaoxa-2-azaoctacosanoic acid, 28-hydroxy-, 1,1-dimethylethyl ester; 2-Methyl-2-propanyl (26-hydroxy-3,6,9,12,15,18,21,24-octaoxahexacos-1-yl)carbamate; Carbamic acid, N-(26-hydroxy-3,6,9,12,15,18,21,24-octaoxahexacos-1-yl)-, 1,1-dimethylethyl ester

Boiling Point

585.1±50.0 °C at 760 mmHg

Density

1.095±0.06 g/cm3 (Predicted)

InChI Key

RRJGWZKZLBILQF-UHFFFAOYSA-N

InChI

InChI=1S/C23H47NO11/c1-23(2,3)35-22(26)24-4-6-27-8-10-29-12-14-31-16-18-33-20-21-34-19-17-32-15-13-30-11-9-28-7-5-25/h25H,4-21H2,1-3H3,(H,24,26)

SMILES

CC(C)(C)OC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCO

t-Boc-N-amido-PEG9-alcohol, provides a PEG-based, amide-bearing tether suitable for connecting targeting and E3-ligase-binding modules while supporting favorable solubility and conformational flexibility. Its protected amine functionality enables controlled coupling strategies, and the terminal alcohol offers a versatile handle for derivatization. Such linkers are widely used in targeted protein degradation workflows to tune linker length, reduce aggregation, and improve overall construct performance. Detailed structural and reactivity considerations follow below.

Structure: The linker features a poly(ethylene glycol) chain terminated by a primary alcohol and incorporating an amide linkage, with a Boc-protected nitrogen providing acid-labile protection. It contains ether linkages characteristic of PEG, along with amide and carbamate functionalities that support stable covalent connectivity and tunable polarity.

Reactivity: The Boc group can be removed under standard acid-mediated deprotection conditions to reveal a reactive amine for subsequent amide or urea-forming couplings. The terminal alcohol can be converted to activated derivatives (for example, halides, mesylates, or carbonates) to enable nucleophilic substitution or ester formation with complementary electrophiles. Coupling steps commonly proceed via carbodiimide-mediated amidation or related amide bond strategies using appropriate bases and polar aprotic solvents.

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* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C₁V₁ = C₂V₂