TCO-PEG24-acid
Cat No.: BP-501751
Purity: 95%
4.5 
TCO-PEG24-acid is a polyethylene glycol (PEG)–based linker bearing a trans-cyclooctene (TCO) functional group and a terminal carboxylic acid, providing a flexible, water-soluble spacer for PROTAC and targeted protein degradation workflows. The long PEG chain length and ether-rich backbone help reduce steric hindrance and improve the effective reach between the ligand moieties attached to the two ends of a degrader construct. In PROTAC design, the TCO handle enables rapid bioorthogonal conjugation via inverse-electron-demand Diels–Alder reactions with tetrazine-containing partners, allowing researchers to assemble or exchange targeting and recruitment modules under mild conditions while minimizing nonspecific reactions. The terminal acid facilitates straightforward coupling to amine- or activated ester–functionalized components, supporting robust synthetic integration into larger degradation systems. As a modular linker, it is valuable for optimizing degrader geometry, tuning intramolecular distance, and improving conjugation efficiency in experimental targeted protein degradation studies.
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* For research and manufacturing use only. Not for human or clinical use.
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TCO-PEG24-acid is a polyethylene glycol-based PROTAC linker designed to provide a flexible, water-compatible spacer between a ligand and a target-binding module. Its functional acid handle supports reliable conjugation strategies, while the TCO moiety enables efficient bioorthogonal coupling for assembling PROTAC constructs. The combination of PEG-mediated solvation and reactive coupling chemistry can improve effective reach and assembly efficiency in targeted protein degradation workflows. Detailed structural and reactivity considerations are provided below.
Structure: The linker comprises a long PEG chain that confers conformational flexibility and hydrophilicity, terminated by an acid functionality for handle-based coupling. It contains a trans-cyclooctene (TCO) motif suitable for rapid inverse-electron-demand cycloaddition. The structure features ether linkages along the PEG backbone and a carboxylic acid for derivatization.
Reactivity: TCO-PEG24-acid is typically used in PROTAC assembly via TCO–tetrazine bioorthogonal ligation, proceeding through an inverse-electron-demand cycloaddition that yields a stable conjugate. Conjugation is commonly performed under aqueous or mixed-solvent conditions compatible with tetrazine partners, with careful control of pH to preserve acid functionality and minimize side reactions. No metal catalysts are required for the cycloaddition step, and reaction efficiency depends on tetrazine reactivity and solvent composition.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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