TCO-PEG8-acid
CAS No.: 2353410-03-2
Cat No.: BP-501206
Purity: 95%
4.5 
TCO-PEG8-acid is a heterobifunctional, polyethylene glycol–based PROTAC linker bearing a strained trans-cyclooctene (TCO) handle and a terminal carboxylic acid for convenient conjugation to a targeting ligand or E3 ligase–binding moiety. The PEG8 chain provides a flexible, hydrophilic spacer that improves solubility and helps reduce steric interference, while the TCO group enables rapid, bioorthogonal ligation to tetrazine-functional partners through an inverse-electron-demand Diels–Alder reaction. In PROTAC construction, this design allows researchers to assemble or exchange components under mild conditions, facilitating modular synthesis and optimization of the effective distance and orientation between the two binding domains. The terminal acid further supports coupling chemistries (e.g., amide formation) to generate well-defined conjugates. As a result, TCO-PEG8-acid is a practical tool for targeted protein degradation research where controlled linker geometry and efficient conjugation are critical for achieving productive ternary complex formation and reliable degradation activity.
Structure of 2353410-03-2
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TCO-PEG8-acid is a PEG-based PROTAC linker designed to connect targeting and recruiting modules while providing conformational flexibility and improved solubility in common organic/aqueous workups. Its functional handles enable efficient conjugation strategies used in targeted protein degradation workflows, supporting the assembly of stable, well-defined heterobifunctional degraders. The detailed structural and synthetic considerations are described below.
Structure: The linker is built on a polyethylene glycol chain incorporating a carboxylic acid terminus and a strained trans-cyclooctene (TCO) moiety. It contains ether linkages typical of PEG, a terminal carboxyl group for coupling, and a cycloalkene suitable for bioorthogonal reactivity, yielding a flexible, polar scaffold.
Reactivity: The carboxylic acid enables amide or ester-forming coupling to complementary amine or alcohol partners under standard peptide-coupling conditions, typically using activating reagents and base in polar aprotic solvents. The TCO group participates in rapid strain-promoted cycloaddition with tetrazines via a bioorthogonal mechanism, often performed under mild, aqueous-compatible conditions to minimize side reactions and preserve linker integrity during PROTAC construction.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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