THP-PEG11-THP
Cat No.: BP-501773
4.5 
THP-PEG11-THP is a homobifunctional polyethylene glycol linker bearing two tetrahydropyran (THP) end groups connected through an extended PEG chain of intermediate length. Structurally, it provides a flexible, hydrophilic spacer that can be positioned between two PROTAC-relevant ligands or between a ligand and a reactive handle, while the terminal THP motifs serve as protected alcohol equivalents that can be unmasked under appropriate conditions to enable controlled conjugation. In PROTAC design, the PEG segment helps reduce steric clashes and improves the effective reach and conformational freedom required for productive ternary complex formation, whereas the terminal THP-derived functionality supports stepwise assembly of the conjugate with defined attachment points. This linker is valuable for researchers optimizing linker length and polarity to tune degradation potency, selectivity, and physicochemical properties such as solubility and stability during synthesis and assay workflows.
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* For research and manufacturing use only. Not for human or clinical use.
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THP-PEG11-THP is a polyethylene glycol-based bifunctional linker designed for constructing PROTACs that connect two binding elements while promoting productive ternary complex formation. Its flexible, hydrophilic PEG segment can improve solubility and reduce steric constraints, supporting efficient recruitment of target proteins. The linker’s two compatible termini enable straightforward conjugation strategies, and the structural and reactivity considerations below describe how it is typically handled in PROTAC synthesis workflows.
Structure: THP-PEG11-THP contains two tetrahydropyran (THP) protected functional handles separated by a long, flexible PEG chain. The structure features ether linkages within the PEG backbone and acetal-type THP groups, yielding a hydrophilic, conformationally adaptable linker suitable for bioconjugation.
Reactivity: THP groups are commonly used as acid-labile protecting groups for alcohol or related functionalities; deprotection is typically performed under mild acidic conditions to regenerate reactive hydroxyl sites. For PROTAC assembly, the regenerated termini can be engaged in standard coupling chemistries (for example, esterification or ether formation) using activated carboxylic acids or electrophilic derivatives, with appropriate base and dry, inert-compatible solvents depending on the coupling partner.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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