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Hydroxy-PEG3-t-butyl ester - CAS 186020-66-6

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Hydroxy-PEG3-t-butyl ester is a protected PEG linker offering hydroxyl functionality for downstream activation. Its t-butyl group ensures synthetic control, while the PEG3 spacer enhances solubility and biocompatibility in ADC linker and payload formulations.

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Molecular Formula
C13H26O6
Molecular Weight
278.34

Hydroxy-PEG3-t-butyl ester

    • Specification
      • Related CAS
        1186025-29-5 (polymer) 892154-71-1 (polymer)
        Purity
        ≥95%
        Solubility
        Soluble in DMSO (10 mm)
        Appearance
        Colorless to light yellow to light orange clear liquid
        Storage
        Store at 2-8°C
        Shipping
        Room temperature, or blue ice upon request.
        IUPAC Name
        tert-butyl 3-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]propanoate
        Synonyms
        HO-PEG3-CH2CH2COOtBu; Hydroxy-PEG3-(CH2)2-Boc; OH-PEG3-TBA; OH-PEG3-CH2CH2COOtBu; HO-PEG3-t-butyl ester; tert-Butyl 12-hydroxy-4,7,10-trioxadodecanoate; 3-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]propionic acid tert-butyl ester; 12-Hydroxy-4,7,10-trioxadodecanoic Acid tert-Butyl Ester; 2-Methyl-2-propanyl 3-{2-[2-(2-hydroxyethoxy)ethoxy]ethoxy}propanoate; Propanoic acid, 3-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]-, 1,1-dimethylethyl ester; tert-Butyl triethylene glycol-O-propionate
    • Properties
      • Boiling Point
        365.8±27.0°C (Predicted)
        Density
        1.052 g/mL at 20°C
        InChI Key
        KSXVEOLRERRELV-UHFFFAOYSA-N
        InChI
        InChI=1S/C13H26O6/c1-13(2,3)19-12(15)4-6-16-8-10-18-11-9-17-7-5-14/h14H,4-11H2,1-3H3
        Canonical SMILES
        CC(C)(C)OC(=O)CCOCCOCCOCCO
        Biological Activity
        Hydroxy-PEG2-(CH2)2-Boc is a uncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Hydroxy-PEG2- (CH2)2-Boc is extracted from patent WO2004008101A2 (compound 196)[1] . In Vitro: ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
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Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2

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* Total Molecular Weight:
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