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Hydroxy-PEG2-t-butyl ester - CAS 133803-81-3

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Hydroxy-PEG2-(CH2)2-Boc is a uncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Hydroxy-PEG2-(CH2)2-Boc is extracted from patent WO2004008101A2 (compound 196).

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Molecular Formula
C11H22O5
Molecular Weight
234.29

Hydroxy-PEG2-t-butyl ester

    • Specification
      • Related CAS
        1186025-29-5 (polymer) 892154-71-1 (polymer)
        Purity
        ≥95%
        Solubility
        Soluble in DMSO (10 mm)
        Appearance
        Pale Yellow or Colorless Oily Liquid
        Storage
        Store at 2-8°C
        Shipping
        Room temperature
        IUPAC Name
        tert-butyl 3-[2-(2-hydroxyethoxy)ethoxy]propanoate
        Synonyms
        HO-PEG2-CH2CH2COOtBu; Hydroxy-PEG2-(CH2)2-Boc; OH-PEG2-TBA; OH-PEG2-CH2CH2COOtBu; HO-PEG2-t-butyl ester; Propanoic acid, 3-[2-(2-hydroxyethoxy)ethoxy]-, 1,1-dimethylethyl ester; t-Butyl 9-hydroxy-4,7-dioxanonanoate; 3-[2-(2-hydroxyethoxy)ethoxy]propionic acid t-butyl ester; 2-Methyl-2-propanyl 3-[2-(2-hydroxyethoxy)ethoxy]propanoate
    • Properties
      • Boiling Point
        321.8±22.0 °C at 760 mmHg
        Density
        1.046±0.1 g/cm3
        InChI Key
        OKOWESVURLUVMD-UHFFFAOYSA-N
        InChI
        InChI=1S/C11H22O5/c1-11(2,3)16-10(13)4-6-14-8-9-15-7-5-12/h12H,4-9H2,1-3H3
        Canonical SMILES
        CC(C)(C)OC(=O)CCOCCOCCO
        Biological Activity
        Hydroxy-PEG2-(CH2)2-Boc is a uncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Hydroxy-PEG2- (CH2)2-Boc is extracted from patent WO2004008101A2 (compound 196)[1] . In Vitro: ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
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L

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Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2

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* Total Molecular Weight:
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Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
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