Tos-PEG1-O-CH2COOH
Cat No.: BP-501877
4.5 
Tos-PEG1-O-CH2COOH is a PEG-based linker bearing a tosyl (Tos) activating group and a terminal carboxymethyl (–O–CH2COOH) functionality. Structurally, it provides a short, flexible ethylene glycol spacer that separates and orients two reactive partners while retaining chemical handles for subsequent conjugation chemistry. In PROTAC design, such linkers are used to connect a ligand that binds an E3 ligase to a ligand that engages the target protein, helping to optimize effective ternary-complex formation by tuning distance, local mobility, and steric compatibility. The tosyl group enables efficient substitution reactions to form stable linkages with nucleophilic groups on the adjacent components, while the terminal carboxylic acid can be used for amide coupling or related derivatization to install the linker into the final construct. This product is valuable for rapid, modular synthesis of targeted degradation probes where careful control of linker length and attachment chemistry is essential for activity.
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* For research and manufacturing use only. Not for human or clinical use.
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Tos-PEG1-O-CH2COOH is a PEG-based PROTAC linker designed to connect a tosyl-protecting handle to a carboxymethyl functional group, enabling modular assembly of targeted protein degraders. Its ether-rich PEG segment supports productive spatial presentation of warhead and E3 ligase-binding elements, while the terminal carboxylic acid provides a reliable handle for coupling strategies. The following sections describe the molecule’s structure and practical reactivity considerations for PROTAC construction.
Structure: The linker contains a PEG-derived ether chain terminating in an O-CH2-COOH motif, incorporating a tosyl (tosylate) group as a leaving-group/activation element. It features ether linkages and an acid functionality, offering hydrophilicity and conformational flexibility typical of PEG-based spacers used in degraders.
Reactivity: The tosyl group can be leveraged for substitution or activation workflows, while the terminal carboxylic acid is suitable for standard amide or ester-forming coupling chemistries. Typical PROTAC assembly uses base-mediated activation of the acid (often via coupling reagents) in polar aprotic solvents, followed by nucleophilic coupling to an amine-bearing partner. Reaction conditions are selected to preserve functional-group compatibility and maintain linker integrity during synthesis.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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