VH 032 Linker 3 is a specialized E3 Ligase Ligand-Linker Conjugate designed to facilitate proteolysis targeting chimera (PROTAC) drug development. Acting as a crucial component in the assembly of PROTAC molecules, VH 032 Linker 3 features the well-established VH032 ligand that selectively binds to the Von Hippel-Lindau (VHL) E3 ubiquitin ligase, tethered to a versatile linker for efficient conjugation to target protein ligands. This compound is ideal for constructing bifunctional molecules capable of recruiting specific proteins for ubiquitination and subsequent degradation via the ubiquitin-proteasome system. VH 032 Linker 3 supports advanced research in targeted protein degradation for applications spanning drug discovery, oncology, and chemical biology. As a member of the E3 Ligase Ligand-Linker Conjugate category, this product is optimized for robust and reproducible PROTAC synthesis, helping researchers accelerate the development of next-generation therapeutics.
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E3 Ligase Ligand-Linker Conjugate
Molecular Formula
C27H39N5O4S.HCl
Molecular Weight
566.158
* For research and manufacturing use only. Not for human or clinical use.
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VH 032 Linker 3 is a specialized E3 ligase ligand-linker conjugate designed for targeted protein degradation research. Derived from the well-established VH032 moiety, which selectively binds to the von Hippel-Lindau (VHL) E3 ubiquitin ligase complex, this linker conjugate enables researchers to construct effective PROTAC molecules. Such tools are instrumental in advancing modern drug discovery and chemical biology by providing a modular platform for recruiting the ubiquitin-proteasome system to specific target proteins.
Mechanism
VH 032 Linker 3 functions by exploiting the cell’s endogenous protein degradation machinery. The VH032 portion acts as a ligand that specifically engages the VHL E3 ligase, while the flexible linker provides the chemical handle required for conjugation to a ligand for the target protein of interest. When incorporated into a PROTAC (Proteolysis Targeting Chimera), VH 032 Linker 3 tethers the E3 ligase to the target protein ligand, promoting the ubiquitination and subsequent proteasomal degradation of the target protein. This mechanism allows for selective and catalytic removal of disease-relevant proteins within cells.
Applications
VH 032 Linker 3 serves as a critical building block for designing and synthesizing VHL-based PROTACs, facilitating targeted protein degradation in various research applications. Its applications include generating custom PROTACs for studying protein function, developing novel therapeutic strategies against 'undruggable' targets, validating drug targets in preclinical settings, and screening for new molecular degraders. Additionally, VH 032 Linker 3 is widely used in pharmaceutical and academic laboratories focusing on oncology, neurodegeneration, and immunology, where modulating protein levels is essential for disease modeling and treatment innovation.
• Specifically designed for high-affinity VHL (von Hippel-Lindau) E3 ligase recruitment in PROTAC applications, ensuring targeted protein degradation.
• Flexible linker structure enables efficient conjugation with diverse warheads, enhancing versatility and yield in PROTAC development workflows.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
Cat No.: BP-100014
Purity: ≥98%
