| Structure |
Catalog |
Product Name |
CAS |
E3 Ligase |
Target |
Inquiry |
![(2S,4R)-1-((S)-2-(2-(2-(2-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)ethoxy)ethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide](https://resource.bocsci.com/structure/2489240-92-6.gif) |
BPL-201773 |
(2S,4R)-1-((S)-2-(2-(2-(2-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)ethoxy)ethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide |
2489240-92-6 |
VHL |
CDK4
CDK6 |
Inquiry |
|
Molecular Weight: 1006.24
Molecular Formula: C52H67N11O8S
Melting Point: 122-124°C
Density: 1.308±0.06 g/cm3
Description: It is a potent and selective CDK4 and CDK6 degrader.
|
![(2S,4R)-1-((S)-14-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)-2-(tert-butyl)-4-oxo-6,9,12-trioxa-3-azatetradecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide](https://resource.bocsci.com/structure/2489240-94-8.gif) |
BPL-201774 |
(2S,4R)-1-((S)-14-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)-2-(tert-butyl)-4-oxo-6,9,12-trioxa-3-azatetradecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide |
2489240-94-8 |
VHL |
CDK4
CDK6 |
Inquiry |
|
Molecular Weight: 1050.29
Molecular Formula: C54H71N11O9S
Melting Point: 96-98°C
Density: 1.299±0.06 g/cm3
Description: It is a potent and selective CDK4 and CDK6 degrader.
|
![(2S,4R)-1-((S)-2-(5-((5-((6-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)hexyl)oxy)pentyl)oxy)pentanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide](https://resource.bocsci.com/structure/2489240-96-0.gif) |
BPL-201775 |
(2S,4R)-1-((S)-2-(5-((5-((6-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)hexyl)oxy)pentyl)oxy)pentanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide |
2489240-96-0 |
VHL |
CDK4
CDK6 |
Inquiry |
|
Molecular Weight: 1146.51
Molecular Formula: C62H87N11O8S
Melting Point: 104-106°C
Density: 1.227±0.06 g/cm3
Description: It is a potent and selective CDK4 and CDK6 degrader.
|
![(2S,4R)-N-(2-((8-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)octyl)oxy)-4-(4-methylthiazol-5-yl)benzyl)-4-hydroxy-1-((S)-3-methyl-2-(1-oxoisoindolin-2-yl)butanoyl)pyrrolidine-2-carboxamide](https://resource.bocsci.com/structure/2489240-99-3.gif) |
BPL-201776 |
(2S,4R)-N-(2-((8-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)octyl)oxy)-4-(4-methylthiazol-5-yl)benzyl)-4-hydroxy-1-((S)-3-methyl-2-(1-oxoisoindolin-2-yl)butanoyl)pyrrolidine-2-carboxamide |
2489240-99-3 |
VHL |
CDK4
CDK6 |
Inquiry |
|
Molecular Weight: 1106.41
Molecular Formula: C61H75N11O7S
Melting Point: 134-138°C
Density: 1.294±0.06 g/cm3
Description: It is a potent and selective CDK4 and CDK6 degrader.
|
![(2S,4R)-N-(2-(2-(2-(2-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)ethoxy)ethoxy)ethoxy)-4-(4-methylthiazol-5-yl)benzyl)-4-hydroxy-1-((S)-3-methyl-2-(1-oxoisoindolin-2-yl)butanoyl)pyrrolidine-2-carboxamide](https://resource.bocsci.com/structure/2489241-01-0.gif) |
BPL-201777 |
(2S,4R)-N-(2-(2-(2-(2-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)ethoxy)ethoxy)ethoxy)-4-(4-methylthiazol-5-yl)benzyl)-4-hydroxy-1-((S)-3-methyl-2-(1-oxoisoindolin-2-yl)butanoyl)pyrrolidine-2-carboxamide |
2489241-01-0 |
VHL |
CDK4
CDK6 |
Inquiry |
|
Molecular Weight: 1110.35
Molecular Formula: C59H71N11O9S
Melting Point: 96-98°C
Density: 1.331±0.06 g/cm3
Description: It is a potent and selective CDK4 and CDK6 degrader.
|
![(2S,4R)-N-(2-(2-(2-(2-(2-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)ethoxy)ethoxy)ethoxy)ethoxy)-4-(4-methylthiazol-5-yl)benzyl)-4-hydroxy-1-((S)-3-methyl-2-(1-oxoisoindolin-2-yl)butanoyl)pyrrolidine-2-carboxamide](https://resource.bocsci.com/structure/2489241-04-3.gif) |
BPL-201778 |
(2S,4R)-N-(2-(2-(2-(2-(2-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)ethoxy)ethoxy)ethoxy)ethoxy)-4-(4-methylthiazol-5-yl)benzyl)-4-hydroxy-1-((S)-3-methyl-2-(1-oxoisoindolin-2-yl)butanoyl)pyrrolidine-2-carboxamide |
2489241-04-3 |
VHL |
CDK4
CDK6 |
Inquiry |
|
Molecular Weight: 1154.41
Molecular Formula: C61H75N11O10S
Melting Point: 118-120°C
Density: 1.321±0.06 g/cm3
Description: It is a potent and selective CDK4 and CDK6 degrader.
|
![(2S,4R)-N-(2-((5-((5-((6-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)hexyl)oxy)pentyl)oxy)pentyl)oxy)-4-(4-methylthiazol-5-yl)benzyl)-4-hydroxy-1-((S)-3-methyl-2-(1-oxoisoindolin-2-yl)butanoyl)pyrrolidine-2-carboxamide](https://resource.bocsci.com/structure/2489241-09-8.gif) |
BPL-201779 |
(2S,4R)-N-(2-((5-((5-((6-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)hexyl)oxy)pentyl)oxy)pentyl)oxy)-4-(4-methylthiazol-5-yl)benzyl)-4-hydroxy-1-((S)-3-methyl-2-(1-oxoisoindolin-2-yl)butanoyl)pyrrolidine-2-carboxamide |
2489241-09-8 |
VHL |
CDK4
CDK6 |
Inquiry |
|
Molecular Weight: 1250.62
Molecular Formula: C69H91N11O9S
Melting Point: 104-108°C
Density: 1.251±0.06 g/cm3
Description: It is a potent and selective CDK4 and CDK6 degrader.
|
![(2S,4R)-N-(2-(2-(2-(2-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)ethoxy)ethoxy)ethoxy)-4-(4-methylthiazol-5-yl)benzyl)-1-((S)-2-(1-cyanocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxypyrrolidine-2-carboxamide](https://resource.bocsci.com/structure/2489241-14-5.gif) |
BPL-201780 |
(2S,4R)-N-(2-(2-(2-(2-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)ethoxy)ethoxy)ethoxy)-4-(4-methylthiazol-5-yl)benzyl)-1-((S)-2-(1-cyanocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxypyrrolidine-2-carboxamide |
2489241-14-5 |
VHL |
CDK4
CDK6 |
Inquiry |
|
Molecular Weight: 1101.34
Molecular Formula: C57H72N12O9S
Melting Point: 118-122°C
Density: 1.38±0.1 g/cm3
Description: It is a potent and selective CDK4 and CDK6 degrader.
|
 |
BPL-201781 |
CST651 |
2489241-16-7 |
VHL |
CDK4
CDK6 |
Inquiry |
|
Molecular Weight: 1094.32
Molecular Formula: C56H72FN11O9S
Melting Point: 120-124°C
Density: 1.38±0.1 g/cm3
Description: It is a potent and selective CDK4 and CDK6 degrader.
|
![(2S,4S)-4-(3-(2-(2-(2-(2-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)ethoxy)ethoxy)ethoxy)ethoxy)phenoxy)-1-((S)-2-cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)-N-((R)-1,2,3,4-tetrahydronaphthalen-1-yl)pyrrolidine-2-carboxamide](https://resource.bocsci.com/structure/2489241-19-0.gif) |
BPL-201782 |
(2S,4S)-4-(3-(2-(2-(2-(2-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)ethoxy)ethoxy)ethoxy)ethoxy)phenoxy)-1-((S)-2-cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)-N-((R)-1,2,3,4-tetrahydronaphthalen-1-yl)pyrrolidine-2-carboxamide |
2489241-19-0 |
XIAP |
CDK4
CDK6 |
Inquiry |
|
Molecular Weight: 1182.48
Molecular Formula: C65H87N11O10
Melting Point: 94-96°C
Density: 1.31±0.1 g/cm3
Description: It is a potent and selective CDK4 and CDK6 degrader.
|
![(2R,3S,4R,5S)-N-(4-((2-(2-(2-(2-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)ethoxy)ethoxy)ethoxy)ethyl)carbamoyl)-2-methoxyphenyl)-3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-neopentylpyrrolidine-2-carboxamide](https://resource.bocsci.com/structure/2489241-23-6.gif) |
BPL-201783 |
(2R,3S,4R,5S)-N-(4-((2-(2-(2-(2-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)ethoxy)ethoxy)ethoxy)ethyl)carbamoyl)-2-methoxyphenyl)-3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-neopentylpyrrolidine-2-carboxamide |
2489241-23-6 |
MDM2 |
CDK4
CDK6 |
Inquiry |
|
Molecular Weight: 1221.25
Molecular Formula: C63H73Cl2F2N11O8
Melting Point: 142-146°C
Density: 1.38±0.1 g/cm3
Description: It is a potent and selective CDK4 and CDK6 degrader.
|
 |
BPL-201784 |
JB159 |
2705844-83-1 |
CRBN |
AURKA |
Inquiry |
|
Molecular Weight: 889.28
Molecular Formula: C45H38ClFN8O9
Density: 1.52±0.1 g/cm3
Description: It is a chemical degrader (PROTAC) by connecting a clinical kinase inhibitor of AURORA-A to E3 ligase-binding molecule. It can induce rapid, durable and highly specific degradation of AURORA-A.
|
 |
BPL-201785 |
JB169 |
2705844-84-2 |
CRBN |
AURKA |
Inquiry |
|
Molecular Weight: 917.35
Molecular Formula: C47H42ClFN8O9
Density: 1.49±0.1 g/cm3
Description: It is a chemical degrader (PROTAC) by connecting a clinical kinase inhibitor of AURORA-A to E3 ligase-binding molecule. It can induce rapid, durable and highly specific degradation of AURORA-A.
|
 |
BPL-201786 |
JB170 |
2705844-82-0 |
CRBN |
AURKA |
Inquiry |
|
Molecular Weight: 963.38
Molecular Formula: C48H44ClFN8O11
Density: 1.49±0.1 g/cm3
Description: It is a chemical degrader (PROTAC) by connecting a clinical kinase inhibitor of AURORA-A to E3 ligase-binding molecule. It can induce rapid, durable and highly specific degradation of AURORA-A.
|
 |
BPL-201787 |
JB171 |
2567930-99-6 |
CRBN |
AURKA |
Inquiry |
|
Molecular Weight: 919.32
Molecular Formula: C46H40ClFN8O10
Density: 1.51±0.1 g/cm3
Description: It is a chemical degrader (PROTAC) by connecting a clinical kinase inhibitor of AURORA-A to E3 ligase-binding molecule. It can induce rapid, durable and highly specific degradation of AURORA-A.
|
 |
BPL-201788 |
JB160 |
2705844-85-3 |
VHL |
AURKA |
Inquiry |
|
Molecular Weight: 1090.68
Molecular Formula: C56H61ClFN9O9S
Density: 1.38±0.1 g/cm3
Description: It is a chemical degrader (PROTAC) by connecting a clinical kinase inhibitor of AURORA-A to E3 ligase-binding molecule. It can induce rapid, durable and highly specific degradation of AURORA-A.
|
 |
BPL-201789 |
JB161 |
2705844-86-4 |
VHL |
AURKA |
Inquiry |
|
Molecular Weight: 1178.78
Molecular Formula: C60H69ClFN9O11S
Density: 1.36±0.1 g/cm3
Description: It is a chemical degrader (PROTAC) by connecting a clinical kinase inhibitor of AURORA-A to E3 ligase-binding molecule. It can induce rapid, durable and highly specific degradation of AURORA-A.
|
 |
BPL-201790 |
Pmd-PEG6-BI |
2485722-78-7 |
CRBN |
BRAF V600E |
Inquiry |
|
Molecular Weight: 1133.24
Molecular Formula: C54H66F2N10O13S
Density: 1.43±0.1 g/cm3
Description: It is a PROTAC directed against BRAF mutant V600E.
|
 |
BPL-201791 |
Pmd-PEG8-BI |
2485722-79-8 |
CRBN |
BRAF V600E |
Inquiry |
|
Molecular Weight: 1221.35
Molecular Formula: C58H74F2N10O15S
Density: 1.40±0.1 g/cm3
Description: It is a PROTAC directed against BRAF mutant V600E.
|
 |
BPL-201792 |
Pmd-1C-PEG3-1C-2C-BI |
2485722-80-1 |
CRBN |
BRAF V600E |
Inquiry |
|
Molecular Weight: 1100.22
Molecular Formula: C53H63F2N11O11S
Density: 1.45±0.1 g/cm3
Description: It is a PROTAC directed against BRAF mutant V600E.
|
