PROTAC Library - PROTAC® / BOC Sciences

Structure	Catalog	Product Name	CAS	E3 Ligase	Target	Inquiry
	BPL-201833	RC-10	2567792-09-8	CRBN	BTK	Inquiry
Molecular Weight: 937.03 Molecular Formula: C49H52N12O8 Boiling Point: 1204.6±65.0°C at 760 Torr Density: 1.43±0.1 g/cm3 Description: It is a reversible covalent BTK PROTAC.
	BPL-201834	IRC-FLT3	2624370-31-4	CRBN	FLT3	Inquiry
Molecular Weight: 901.04 Molecular Formula: C47H56N12O7 Density: 1.35±0.1 g/cm3 Description: It is an irreversible covalent FLT3 PROTAC.
	BPL-201835	RNC-FLT3	2624370-32-5	CRBN	FLT3	Inquiry
Molecular Weight: 903.06 Molecular Formula: C47H58N12O7 Density: 1.34±0.1 g/cm3 Description: It is a reversible noncovalent FLT3 PROTAC.
	BPL-201836	RC-FLT3	2624370-33-6	CRBN	FLT3	Inquiry
Molecular Weight: 954.11 Molecular Formula: C50H59N13O7 Density: 1.34±0.1 g/cm3 Description: It is a reversible covalent FLT3 PROTAC.
	BPL-201837	dTAGV-1	2451573-86-5	VHL	FKBP12 F36V	Inquiry
Molecular Weight: 1247.56 Molecular Formula: C68H90N6O14S Boiling Point: 1274.6±65.0°C at 760 Torr Density: 1.208±0.06 g/cm3 Description: dTAGV-1 is an exclusively selective VHL-recruited dTAG molecule for rapid degradation of FKBP12F36V-tagged proteins.
	BPL-201838	dTAG-63	2451573-88-7	VHL	FKBP12 F36V	Inquiry
Molecular Weight: 1309.59 Molecular Formula: C69H92N6O17S Boiling Point: 1300.4±65.0°C at 760 Torr Density: 1.226±0.06 g/cm3 Description: dTAG-63 is a selective VHL-recruited dTAG molecule for rapid degradation of FKBP12F36V-tagged proteins.
	BPL-201839	N-(8-((2-(2,6-Dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)amino)-8-oxooctyl)-2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzamide	2400984-57-6	CRBN	PARP1	Inquiry
Molecular Weight: 680.74 Molecular Formula: C37H37FN6O6 Density: 1.42±0.1 g/cm3 Description: It is a probe-quality degrader for Poly (ADP-ribose) polymerase-1 (PARP-1).
	BPL-201840	N-(11-((2-(2,6-Dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)amino)-11-oxoundecyl)-2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzamide	2400984-61-2	CRBN	PARP1	Inquiry
Molecular Weight: 722.82 Molecular Formula: C40H43FN6O6 Density: 1.37±0.1 g/cm3 Description: It is a probe-quality degrader for Poly (ADP-ribose) polymerase-1 (PARP-1).
	BPL-201841	N-(12-((2-(2,6-Dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)amino)-12-oxododecyl)-2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzamide	2400984-63-4	CRBN	PARP1	Inquiry
Molecular Weight: 736.85 Molecular Formula: C41H45FN6O6 Density: 1.36±0.1 g/cm3 Description: It is a probe-quality degrader for Poly (ADP-ribose) polymerase-1 (PARP-1).
	BPL-201842	MTX-23	2488296-74-6	VHL	AR AR-V7	Inquiry
Molecular Weight: 882.07 Molecular Formula: C43H53F2N7O7S2 Density: 1.312±0.06 g/cm3 Description: MTX-23 is a novel PROTAC that degrades AR-V7 and AR-FL. It can be used for CRPC resistance to second-line antiandrogen therapy.
	BPL-201843	N1-(4-(6-((S)-2-((2S,3R)-3-Amino-2-hydroxy-4-phenylbutanamido)-4-methylpentanamido)hexanamido)phenyl)-N8-hydroxyoctanediamide		cIAP1	HDAC1 HDAC6 HDAC8	Inquiry
Molecular Weight: 682.86 Molecular Formula: C36H54N6O7 Description: It is a Bestatin-SAHA hybrid with dual inhibitory activity against APN and HDAC.
	BPL-201844	N1-((11S,14S,15R)-15-Amino-14-hydroxy-11-isobutyl-10,13-dioxo-16-phenyl-3,6-dioxa-9,12-diazahexadecyl)-N3-hydroxyisophthalamide		cIAP1	HDAC1 HDAC6 HDAC8	Inquiry
Molecular Weight: 601.70 Molecular Formula: C30H43N5O8 Description: It is a Bestatin-SAHA hybrid with dual inhibitory activity against APN and HDAC.
	BPL-201845	3-((11S,14S,15R)-15-Amino-14-hydroxy-11-isobutyl-10,13-dioxo-16-phenyl-3,6-dioxa-9,12-diazahexadecanamido)-N-hydroxybenzamide		cIAP1	HDAC1 HDAC6 HDAC8	Inquiry
Molecular Weight: 587.67 Molecular Formula: C29H41N5O8 Description: It is a Bestatin-SAHA hybrid with dual inhibitory activity against APN and HDAC.
	BPL-201846	2-((2-((4-(4-(6-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)hexyl)piperazin-1-yl)-2-methoxyphenyl)amino)-5-(trifluoromethyl)pyridin-4-yl)amino)-N-methylbenzamide	2414478-37-6	CRBN	FAK	Inquiry
Molecular Weight: 913.96 Molecular Formula: C46H50F3N9O8 Boiling Point: 1069.4±65.0°C at 760 Torr Density: 1.365±0.06 g/cm3 Description: It is a PROTAC that chemically induces the degradation of FAK-ALK for cancer therapy.
	BPL-201847	MFH-5-103-1	2414478-40-1	CRBN	AURKA CDK10 CDK7 FAK MAPK7 PTK2B RPS6KA1 RPS6KA3 STK33 Wee1	Inquiry
Molecular Weight: 944.97 Molecular Formula: C46H51F3N10O9 Boiling Point: 1095.6±65.0°C at 760 Torr Density: 1.395±0.06 g/cm3 Description: It is a PROTAC that chemically induces the degradation of FAK-ALK for cancer therapy.
	BPL-201848	2-((2-((4-(4-(8-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)acetamido)octyl)piperazin-1-yl)-2-methoxyphenyl)amino)-5-(trifluoromethyl)pyridin-4-yl)amino)-N-methylbenzamide	2414478-41-2	CRBN	FAK	Inquiry
Molecular Weight: 941.03 Molecular Formula: C48H55F3N10O7 Boiling Point: 1087.9±65.0°C at 760 Torr Density: 1.348±0.06 g/cm3 Description: It is a PROTAC that chemically induces the degradation of FAK-ALK for cancer therapy.
	BPL-201849	MFH-5-116-1	2414478-42-3	CRBN	AURKA FAK NUAK1 PTK2B RPS6KA1 RPS6KA3 STK33 Wee1	Inquiry
Molecular Weight: 883.97 Molecular Formula: C46H52F3N9O6 Boiling Point: 1004.3±65.0°C at 760 Torr Density: 1.342±0.06 g/cm3 Description: It is a PROTAC that chemically induces the degradation of FAK-ALK for cancer therapy.
	BPL-201850	N-(8-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)octyl)-4-((4-((3-(methylsulfonyl)benzyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzamide	2414478-43-4	CRBN	FAK	Inquiry
Molecular Weight: 906.94 Molecular Formula: C43H45F3N8O9S Density: 1.410±0.06 g/cm3 Description: It is a PROTAC that chemically induces the degradation of FAK-ALK for cancer therapy.
	BPL-201851	2-((2-((4-(1-(6-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)hexyl)piperidin-4-yl)-2-isopropoxy-5-methylphenyl)amino)-5-(trifluoromethyl)pyridin-4-yl)amino)-N-methylbenzamide	2414478-45-6	CRBN	FAK	Inquiry
Molecular Weight: 955.05 Molecular Formula: C50H57F3N8O8 Boiling Point: 1047.2±65.0°C at 760 Torr Density: 1.312±0.06 g/cm3 Description: It is a PROTAC that chemically induces the degradation of FAK-ALK for cancer therapy.
	BPL-201852	3-(5-(4-(2-(1-(5-((1R,3R)-2-(2-Fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)pyrimidin-2-yl)piperidin-4-yl)ethyl)piperazin-1-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione	2500656-40-4	CRBN	ER	Inquiry
Molecular Weight: 775.97 Molecular Formula: C44H54FN9O3 Density: 1.270±0.06 g/cm3 Description: It is a PROTAC that degrades estrogen receptor (ER) for the treatment of breast cancer.