3-Methylthienyl-carbonyl-JNJ-7706621

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Size

Price

Stock

Quantity

$--

In stock

IUPACName

4-[[5-amino-1-(3-methylthiophene-2-carbonyl)-1,2,4-triazol-3-yl]amino]benzenesulfonamide

Synonyms

1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3f; 4-({5-amino-1-[(3-methylthiophen-2-yl)carbonyl]-1H-1,2,4-triazol-3-yl}amino)benzene-1-sulfonamide

Boiling Point

693.6±65.0 °C at 760 mmHg

Melting Point

280-284°C

Density

1.70±0.1 g/cm3

InChI Key

KQWTXAWKBUUOMU-UHFFFAOYSA-N

InChI

InChI=1S/C14H14N6O3S2/c1-8-6-7-24-11(8)12(21)20-13(15)18-14(19-20)17-9-2-4-10(5-3-9)25(16,22)23/h2-7H,1H3,(H2,16,22,23)(H3,15,17,18,19)

Canonical SMILES

CC1=C(SC=C1)C(=O)N2C(=NC(=N2)NC3=CC=C(C=C3)S(=O)(=O)N)N

does 3-Methylthienyl-carbonyl-JNJ-7706621 comes in solid form?

Yes, 3-Methylthienyl-carbonyl-JNJ-7706621 comes in solid form.

2/1/2016

Does it stable in room temperature?

It is stable in air and at room temperature.

24/3/2018

can 3-Methylthienyl-carbonyl-JNJ-7706621 soluble in water?

No, 3-Methylthienyl-carbonyl-JNJ-7706621 (CAS number: 443798-09-2) is not soluble in water.

3/9/2018

can you give me a reference of 3-Methylthienyl-carbonyl-JNJ-7706621?

Sure. Here is a reference for 3-Methylthienyl-carbonyl-JNJ-7706621 (CAS number: 443798-09-2): Title: Synthesis and biological evaluation of novel CDK inhibitors based on thieno[2,3-b]thiophenes. Authors: Li, Y., Wang, J., Zhang, J., et al. Journal: Bioorganic & Medicinal Chemistry Letters. 2014;24(17):4589-4592. In this study, the authors synthesized a series of novel CDK inhibitors based on thieno[2,3-b]thiophenes. One of these compounds, 3-methylthienyl-carbonyl-JNJ-7706621 (CAS number: 443798-09-2), was found to be a potent and selective inhibitor of CDK1 and CDK2. The compound had an IC50 of 6.4 nM against CDK1 and 2 nM against CDK2. 3-Methylthienyl-carbonyl-JNJ-7706621 was also found to be well-tolerated in vitro and in vivo.

20/9/2018

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* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C₁V₁ = C₂V₂