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3-Methylthienyl-carbonyl-JNJ-7706621 - CAS 443798-09-2

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3-Methylthienyl-carbonyl-JNJ-7706621 is a potent and selective cyclin-dependent kinase (CDK) inhibitor, with IC50s of 6.4 nM and 2 nM for CDK1/cyclin B and CDK2/cyclin A, respectively. It also has strong inhibitory effect on GSK-3 (IC50 = 0.041 μM) and modest potency against CDK4, VEGF-R2 and FGF-R2 with IC50s of 0.11, 0.13 and 0.22 μM, respectively. It can be used in cancer research.

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Molecular Formula
C14H14N6O3S2
Molecular Weight
378.43

3-Methylthienyl-carbonyl-JNJ-7706621

    • Specification
      • IUPAC Name
        4-[[5-amino-1-(3-methylthiophene-2-carbonyl)-1,2,4-triazol-3-yl]amino]benzenesulfonamide
        Synonyms
        1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3f; 4-({5-amino-1-[(3-methylthiophen-2-yl)carbonyl]-1H-1,2,4-triazol-3-yl}amino)benzene-1-sulfonamide
    • Properties
      • Boiling Point
        693.6±65.0 °C at 760 mmHg
        Melting Point
        280-284°C
        Density
        1.70±0.1 g/cm3
        InChI Key
        KQWTXAWKBUUOMU-UHFFFAOYSA-N
        InChI
        InChI=1S/C14H14N6O3S2/c1-8-6-7-24-11(8)12(21)20-13(15)18-14(19-20)17-9-2-4-10(5-3-9)25(16,22)23/h2-7H,1H3,(H2,16,22,23)(H3,15,17,18,19)
        Canonical SMILES
        CC1=C(SC=C1)C(=O)N2C(=NC(=N2)NC3=CC=C(C=C3)S(=O)(=O)N)N
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It is commonly abbreviated as: C1V1 = C2V2

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Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
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