Azido-PEG4-acetic Acid - CAS 201467-81-4

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N33-TEG-COOH is a PROTAC linker containing four polyethylene glycol (PEG) units. N33-TEG-COOH is a PEG derivative containing an azide group with a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) to form a stable amide bond.

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Molecular Formula C10H19N3O6
Molecular Weight 277.27

Azido-PEG4-acetic Acid

Synonyms 2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]acetic acid; 2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]acetic acid
Solubility DMSO : ≥ 100 mg/mL
Storage Pure form
-20°C
3 years



4°C
2 years


In solvent
-80°C
6 months



-20°C
1 month
Shipping Room temperature in continental US; may vary elsewhere
InChI Key YHTABJLSZLHRFV-UHFFFAOYSA-N
InChI InChI=1S/C10H19N3O6/c11-13-12-1-2-16-3-4-17-5-6-18-7-8-19-9-10(14)15/h1-9H2,(H,14,15)
Canonical SMILES C(COCCOCCOCCOCC(=O)O)N=[N+]=[N-]

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