Amino-PEG11-CH2COOH
Cat No.: BP-502051
Purity: ≥95%
4.5 
Amino-PEG11-CH2COOH is a polyethylene glycol (PEG) linker bearing a terminal primary amine and a carboxymethyl group, providing a flexible, hydrophilic chain suited for bioconjugation. Structurally, it consists of an extended PEG backbone with two reactive termini that can be used for orthogonal coupling: the amino group enables amide or urea formation with activated carboxylic acids, while the carboxylic acid can be converted to NHS/EDC-type activated intermediates for attachment to complementary nucleophiles. In PROTAC design, such PEG linkers help tune the effective spatial arrangement between the ligand-binding “warhead” modules and the recruited E3 ligase moiety, reducing steric clashes and improving productive ternary complex formation. The long, flexible linker can also enhance aqueous solubility and mitigate aggregation, facilitating synthesis and downstream biochemical evaluation. This makes Amino-PEG11-CH2COOH a practical building block for constructing targeted protein degraders and for systematically optimizing linker length and geometry in degradation assays.
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* For research and manufacturing use only. Not for human or clinical use.
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Amino-PEG11-CH2COOH is a polyethylene glycol-based linker designed to connect targeting ligands in PROTAC constructs while providing favorable solubility, conformational flexibility, and reduced nonspecific interactions. Its terminal amino and carboxymethyl functionalities enable robust, widely used bioconjugation strategies for assembling degraders under standard synthetic conditions. The detailed structural and reactivity considerations below describe how this linker supports efficient PROTAC synthesis and downstream purification.
Structure: The linker comprises a PEG (polyethylene glycol) chain terminated by a primary amino group and a carboxymethyl acid, featuring ether linkages along the PEG backbone and a methylene spacer adjacent to the terminal carboxylic acid. It is typically flexible, hydrophilic, and suitable for aqueous-phase handling.
Reactivity: The terminal amino group can participate in amide-forming coupling reactions with activated carboxylic acids (e.g., via common carbodiimide or activated ester chemistries), while the terminal carboxylic acid can be converted to reactive intermediates for subsequent conjugation to complementary nucleophiles. PROTAC assembly is commonly performed in polar organic solvents or buffered mixtures, using base and coupling reagents to drive condensation while minimizing side reactions such as hydrolysis.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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