Amino-PEG14-alcohol
CAS No.: 34214-89-6
Cat No.: BP-501715
4.5 
Amino-PEG14-alcohol is a polyethylene glycol (PEG) linker bearing a terminal primary amine and a terminal hydroxyl group. Structurally, it is a linear PEG chain of extended length that provides a flexible, hydrophilic spacer between two reactive handles, with the amine commonly used for amide-bond formation or carbamate/urea coupling and the alcohol enabling ester or ether chemistry depending on the chosen activation strategy. In PROTAC and targeted protein degradation designs, such bifunctional PEG linkers help tune the spatial separation and relative orientation between the ligand that recruits an E3 ligase and the ligand that binds the target protein, thereby improving productive ternary complex formation while often reducing nonspecific hydrophobic interactions. Its value for research lies in enabling systematic linker-length and geometry optimization, supporting robust synthesis of conjugates and facilitating downstream biochemical evaluation of degradation potency and selectivity.
Structure of 34214-89-6
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Amino-PEG14-alcohol is a polyethylene glycol-based linker designed to support targeted protein degradation workflows by enabling robust conjugation between a ligand and an E3-recruiting or target-binding module in PROTAC constructs. Its PEG-rich chain provides conformational flexibility and improves solubility, which can help maintain productive ternary complex formation. The sections below describe the linker’s structure and the practical considerations for assembling PROTACs using this material.
Structure: Amino-PEG14-alcohol comprises a terminal primary amine and a terminal alcohol connected through a PEG ether backbone. The repeating ethylene glycol units provide polyether oxygen atoms that confer hydrophilicity and flexibility. The molecule contains C–O ether linkages and C–N and O–H functional groups suitable for orthogonal derivatization.
Reactivity: The primary amine and alcohol enable common PROTAC assembly strategies, including amide formation via carboxylic acid activation and ether/ester coupling depending on the electrophile. Typical approaches use activated carboxylic acids (e.g., acid chlorides or activated esters) with base in polar organic solvents, or coupling reagents such as carbodiimides for amide bond construction. For selective conjugation, orthogonal protection of one functional group is often employed, followed by deprotection under mild conditions to preserve linker integrity.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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