Amino-PEG5-alcohol

≥95%

Soluble in DMSO (10 mm)

Pale Yellow or Colorless Oily Matter

Store at 2-8°C

Room temperature, or blue ice upon request.

2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]ethanol

NH2-PEG5-OH; 14-Amino-3,6,9,12-tetraoxatetradecan-1-ol

346.3±0.0 °C at 760 mmHg

1.1±0.0 g/cm3

DEOUHEFHTMMUCM-UHFFFAOYSA-N

InChI=1S/C10H23NO5/c11-1-3-13-5-7-15-9-10-16-8-6-14-4-2-12/h12H,1-11H2

C(COCCOCCOCCOCCO)N

NH2-PEG5-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. NH2-PEG5-OH is also a noncleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2] . In Vitro: PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1] . ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2] .