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Amino-PEG5-alcohol - CAS 34188-11-9

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NH2-PEG5-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. NH2-PEG5-OH is also a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

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Molecular Formula
C10H23NO5
Molecular Weight
237.29

Amino-PEG5-alcohol

    • Specification
      • Related CAS
        933789-97-0 (polymer)
        Purity
        ≥95%
        Solubility
        Soluble in DMSO (10 mm)
        Appearance
        Pale Yellow or Colorless Oily Matter
        Storage
        Store at 2-8°C
        Shipping
        Room temperature, or blue ice upon request.
        IUPAC Name
        2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]ethanol
        Synonyms
        NH2-PEG5-OH; 14-Amino-3,6,9,12-tetraoxatetradecan-1-ol
    • Properties
      • Boiling Point
        346.3±0.0 °C at 760 mmHg
        Density
        1.1±0.0 g/cm3
        InChI Key
        DEOUHEFHTMMUCM-UHFFFAOYSA-N
        InChI
        InChI=1S/C10H23NO5/c11-1-3-13-5-7-15-9-10-16-8-6-14-4-2-12/h12H,1-11H2
        Canonical SMILES
        C(COCCOCCOCCOCCO)N
        Biological Activity
        NH2-PEG5-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. NH2-PEG5-OH is also a noncleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2] . In Vitro: PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1] . ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2] .
    • Preparing Stock Solutions
      • ConcentrationVolumeMass1 mg5 mg10 mg
        1 mM4.2143 mL21.0713 mL42.1425 mL
        5 mM0.8429 mL4.2143 mL8.4285 mL
        10 mM0.4214 mL2.1071 mL4.2143 mL
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