Amino-PEG7-alcohol

Amino-PEG7-alcohol is a polyethylene glycol-based linker building block designed to support PROTAC assembly by providing a flexible, hydrophilic spacer and a functional handle for conjugation. Its ether-rich backbone helps tune solubility and conformational freedom between the target-binding ligand and the E3-recruiting moiety, which can improve productive ternary complex formation. Detailed structural and reactivity guidance is provided below.

Structure: The linker contains an amino functional group and a terminal alcohol, connected through a PEG chain composed of repeating ether units. This architecture provides flexible C–O and C–C connectivity, with multiple ether oxygen atoms that support hydrogen-bonding and enhanced polarity.

Reactivity: The amino group is suitable for nucleophilic coupling strategies such as amide bond formation with activated carboxylic acids, or for carbamate formation using activated carbonyl derivatives. The terminal alcohol can participate in esterification or ether-forming reactions under standard coupling conditions. Typical approaches use coupling reagents and base in polar aprotic solvents, with reaction progress monitored by chromatographic methods to ensure clean functionalization.