Azido-PEG12-alcohol
CAS No.: 1111239-69-0
Cat No.: BP-501468
4.5 
Azido-PEG12-alcohol is a functionalized polyethylene glycol (PEG) linker bearing a terminal azide group and a primary alcohol at the other end, providing a flexible, hydrophilic spacer with an extended chain length suitable for modular PROTAC construction. The azide enables efficient bioorthogonal conjugation via copper-catalyzed or strain-promoted azide–alkyne cycloaddition, allowing researchers to attach the linker to complementary handles on targeting ligands (e.g., E3 ligase binders) or on warhead moieties without disrupting key binding pharmacophores. The terminal alcohol can further support derivatization (for example, through ester or ether formation) to tune solubility, linker polarity, and the effective distance and orientation between recruited proteins. In targeted protein degradation research, such PEG-based linkers are widely used to optimize ternary complex formation and to mitigate steric or electrostatic mismatches, improving the likelihood of productive ubiquitination and degradation.
Structure of 1111239-69-0
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Azido-PEG12-alcohol is a PEG-based bifunctional linker designed for efficient conjugation in targeted protein degradation workflows. Its azide handle enables versatile click chemistry to assemble PROTACs under mild conditions, while the terminal alcohol supports downstream functionalization and controlled attachment to targeting ligands. The PEG scaffold provides conformational flexibility and improved solubility, often beneficial for maintaining productive ternary complex formation. Detailed structural and reactivity considerations are provided below.
Structure: The linker comprises a polyethylene glycol chain terminated by an azide group and a primary alcohol. It contains ether linkages within the PEG backbone, an alkyl alcohol terminus, and an azide functionality suited for bioorthogonal reactions. Overall, it is flexible, hydrophilic, and compatible with aqueous PROTAC assembly.
Reactivity: The azide group is commonly used in copper-catalyzed azide–alkyne cycloaddition or strain-promoted azide–alkyne cycloaddition to connect PROTAC fragments. For copper-catalyzed routes, typical conditions use Cu(I) generated in situ with appropriate ligands and a compatible solvent system, while mild temperatures help preserve sensitive ligands. The alcohol terminus can be converted to activated derivatives (e.g., via standard esterification or carbamate-forming strategies) to enable coupling to nucleophilic groups on targeting moieties.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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