Azido-PEG6-azide
CAS No.: 1243536-56-2
Cat No.: BP-501660
4.5 
Azido-PEG6-azide is a homobifunctional polyethylene glycol linker bearing terminal azide groups, providing a flexible, hydrophilic chain that separates conjugated partners and reduces steric and nonspecific interactions. Structurally, it consists of a PEG segment of defined length terminated by azide functional groups, enabling chemoselective “click” reactions with complementary alkyne-bearing moieties (e.g., propargylated ligands or handles on E3 ligands and target-binding warheads). In PROTAC design, this linker serves as a modular spacer that can connect two functional components while maintaining their independent binding and promoting productive ternary complex formation through controlled spatial presentation. Its PEG backbone improves aqueous solubility and can enhance conjugate stability during synthesis and handling, facilitating reproducible assembly of degradation constructs. Overall, Azido-PEG6-azide is a useful reagent for constructing PROTACs and related targeted protein degradation tools where robust, orthogonal conjugation is required.
Structure of 1243536-56-2
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Azido-PEG6-azide is a polyethylene glycol-based bifunctional linker bearing terminal azide groups, designed to support modular PROTAC assembly through bioorthogonal conjugation. Its flexible PEG scaffold helps decouple steric constraints between targeting ligands and recruited E3 ligase binders, improving productive ternary complex formation. The two azide handles enable orthogonal attachment strategies, and the molecule is described in detail below for structure and reactivity considerations.
Structure: Azido-PEG6-azide consists of a flexible PEG chain terminated by two azide functional groups. It contains ether linkages along the polymer backbone and terminal N3 substituents, providing a polar, water-compatible scaffold with chemical stability under standard handling conditions.
Reactivity: The azide termini participate in copper-catalyzed azide–alkyne cycloaddition or strain-promoted azide–alkyne cycloaddition, enabling efficient ligation to alkyne-functional partners under mild, bioorthogonal conditions. Typical approaches use Cu(I) sources with appropriate ligands, or copper-free systems to minimize metal effects. Solvents are selected to maintain solubility of both conjugates while preserving linker integrity during PROTAC synthesis.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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