Biotin-PEG8-alcohol
CAS No.: 2182601-20-1
Cat No.: BP-501634
4.5 
Biotin-PEG8-alcohol is a biotinylated, polyethylene glycol (PEG) linker terminating in a primary alcohol, featuring a PEG chain of eight ethylene glycol units that provides hydrophilicity, flexibility, and reduced nonspecific interactions. In PROTAC and targeted degradation workflows, this linker serves as a modular conjugation handle: the biotin moiety enables strong, high-affinity capture by streptavidin or avidin-functionalized surfaces, beads, or detection reagents, while the PEG spacer helps maintain productive spatial separation between the biotin tag and the attached molecular partners. The terminal alcohol allows straightforward chemical derivatization (for example, conversion to activated carbonate/ester or other coupling forms) to connect the linker to ligands, handles, or reporter groups without substantially perturbing binding. Its utility lies in enabling controlled assembly, purification, and analytical tracking of PROTAC constructs, facilitating optimization of linker length and conjugation strategies in targeted protein degradation research.
Structure of 2182601-20-1
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Biotin-PEG8-alcohol is a polyethylene glycol (PEG)-based linker designed to support PROTAC assembly by providing a flexible, hydrophilic spacer and a convenient terminal functional handle. Its biotin motif enables strong affinity-based capture and practical workflow compatibility in targeted protein degradation research, while the PEG chain helps tune solubility and reduce steric interference between binding modules. The detailed structural and synthetic considerations are provided below.
Structure: The linker features a biotin-derived moiety connected to a PEG chain terminated with a primary alcohol. It contains ether linkages within the PEG segment and amide/heterocyclic elements associated with biotin, yielding a flexible, water-compatible scaffold. The terminal alcohol offers a reactive functional group for further conjugation.
Reactivity: The primary alcohol can be converted into PROTAC-compatible derivatives via standard alcohol activation chemistry, enabling coupling to electrophilic partners under mild conditions. Typical approaches include formation of activated esters or carbonate-type intermediates, followed by nucleophilic substitution with amine- or hydrazide-bearing components. Solvent systems are commonly selected to balance PEG solubility and reagent compatibility, and catalysts are chosen according to the activation strategy.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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