Name: Benzyl-PEG4-THP
Brand: BOC Sciences
Rating: 5 (1 reviews)

Size

Price

Stock

Quantity

$--

In stock

Purity

≥95%

Appearance

Pale Yellow Oily Matter

Storage

Store at 2-8°C

Shipping

Room temperature in continental US; may vary elsewhere.

IUPACName

2-[2-[2-[2-(2-phenylmethoxyethoxy)ethoxy]ethoxy]ethoxy]oxane

Synonyms

2H-Pyran, tetrahydro-2-[(13-phenyl-3,6,9,12-tetraoxatridec-1-yl)oxy]-; 2-[2-[2-[2-[2-(Benzyloxy)ethoxy]ethoxy]ethoxy]ethoxy]tetrahydro-2H-pyran; 2-((1-phenyl-2,5,8,11-tetraoxatridecan-13-yl)oxy)tetrahydro-2H-pyran

Boiling Point

471.2±45.0°C at 760 mmHg

Density

1.1±0.1 g/cm3

InChI Key

KNXMANKMVQASTE-UHFFFAOYSA-N

InChI

InChI=1S/C20H32O6/c1-2-6-19(7-3-1)18-24-15-14-22-11-10-21-12-13-23-16-17-26-20-8-4-5-9-25-20/h1-3,6-7,20H,4-5,8-18H2

SMILES

C1CCOC(C1)OCCOCCOCCOCCOCC2=CC=CC=C2

Benzyl-PEG4-THP is a polyethylene glycol–based linker bearing a benzyl group and a tetrahydropyranyl (THP) protecting functionality, designed to support modular PROTAC assembly and controlled attachment of warheads and ligands. Its ether-rich PEG segment promotes solubility and conformational flexibility, while the THP handle enables orthogonal chemical manipulation during synthesis. The benzyl substituent provides a robust anchoring motif that can be leveraged for stepwise coupling strategies.

Structure: The linker contains an ether-rich PEG chain that provides flexible, hydrophilic character, coupled to a benzyl substituent and a THP (tetrahydropyran) acetal moiety. It features stable C–O and C–C bonds typical of PEG ethers and acetal-protected alcohol derivatives, supporting compatibility with common organic synthesis conditions.

Reactivity: The THP acetal is suited for acid-mediated deprotection to reveal an alcohol for subsequent conjugation steps, following established acetal hydrolysis principles. PROTAC linker installation typically employs standard coupling chemistries for alcohol-derived intermediates, using appropriate activating agents under controlled conditions. Solvent choice should balance PEG solubility and reaction kinetics, and catalysts or acids used for THP removal should be selected to minimize side reactions on ether linkages.

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* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C₁V₁ = C₂V₂